Regulatory and evolutionary roles of pseudo gamma-butyrolactone receptors in antibiotic biosynthesis and resistance
文献类型：期刊论文
| 作者 | Xu, Gangming; Yang, Suiqun |
| 刊名 | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
 |
| 出版日期 | 2019-12-01 |
| 卷号 | 103期号:23-24页码:9373-9378 |
| 关键词 | Microbial hormone gamma-butyrolactone Quorum sensing Antibiotic resistance |
| ISSN号 | 0175-7598 |
| DOI | 10.1007/s00253-019-10219-0 |
| 通讯作者 | Xu, Gangming(aericxu@gmail.com) |
| 英文摘要 | Bacteria modulate their physiological behavior by responding to various signal molecules. The signals are received by cognate receptors, which usually mediate transcriptional regulation. Streptomyces employ gamma-butyrolactones (GBLs) and cognate GBL receptors (GblRs) to regulate secondary metabolism and morphological development. However, there are additional transcriptional regulators called pseudo GblR regulators, which cannot bind GBLs and are not directly associated with GBL synthase. The pseudo GblR regulators may act as transcriptional repressors and respond to antibiotic signals. They play regulatory roles in coordination of antibiotic biosynthesis by connecting the hormone feed-forward loops and the antibiotic feedback loops. As the TetR family members, they might also have evolutionary roles between the transcriptional regulators of quorum sensing and antibiotic resistance. Understanding the regulatory and evolutionary roles of the pseudo GblR family would be helpful for fine-tuning regulation of antibiotic biosynthesis and resistance. |
| 资助项目 | National Natural Science Foundation of China[31570038] ; National Natural Science Foundation of China[31200042] |
| WOS研究方向 | Biotechnology & Applied Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000509524600014 |
| 出版者 | SPRINGER |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/164421]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Xu, Gangming |
| 作者单位 | Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Gangming,Yang, Suiqun. Regulatory and evolutionary roles of pseudo gamma-butyrolactone receptors in antibiotic biosynthesis and resistance[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2019,103(23-24):9373-9378. |
| APA | Xu, Gangming,&Yang, Suiqun.(2019).Regulatory and evolutionary roles of pseudo gamma-butyrolactone receptors in antibiotic biosynthesis and resistance.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,103(23-24),9373-9378. |
| MLA | Xu, Gangming,et al."Regulatory and evolutionary roles of pseudo gamma-butyrolactone receptors in antibiotic biosynthesis and resistance".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 103.23-24(2019):9373-9378. |
入库方式： OAI收割
来源：海洋研究所
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