Dietary Recombinant Phycoerythrin Modulates the Gut Microbiota of H22 Tumor-Bearing Mice
文献类型:期刊论文
作者 | Qi, Hongtao6,7; Liu, Ying1; Qi, Xin8; Liang, Hui2; Chen, Huaxin; Jiang, Peng3,4,5; Wang, Dongfeng6 |
刊名 | MARINE DRUGS |
出版日期 | 2019-12-01 |
卷号 | 17期号:12页码:17 |
关键词 | recombinant phycoerythrin anti-tumor and immunomodulatory effects intestinal flora high-throughput sequencing microbial barrier |
DOI | 10.3390/md17120665 |
通讯作者 | Jiang, Peng(jiangpeng@qdio.ac.cn) ; Wang, Dongfeng(wangdf@ouc.edu.cn) |
英文摘要 | Normal intestinal flora is widely involved in many functions of the host: nutritional metabolism; maintenance of intestinal microecological balance; regulation of intestinal endocrine function and nerve signal transduction; promotion of intestinal immune system development and maturation; inhibition of pathogenic bacteria growth and colonization, reduction of its invasion to intestinal mucosa, and so on. In recent years, more and more studies have shown that intestinal flora is closely related to the occurrence, development, and treatment of various tumors. It is indicated that recombinant phycoerythrin (RPE) has significant anti-tumor and immunomodulatory effects. However, little is known about the mechanism of the effect of oral (or intragastric) administration of RPE on gut microbiota in tumor-bearing animals. In this study, using high-throughput 16S rDNA sequencing, we examined the response of gut microbiota in H22-bearing mice to dietary RPE supplementation. The results showed that the abundance of beneficial bacteria in the mice intestinal flora decreased and that of the detrimental flora increased after inoculation with tumor cells (H22); following treatment with dietary RPE, the abundance of beneficial bacteria in the intestinal flora significantly increased and that of detrimental bacteria decreased. In this study, for the first time, it was demonstrated that dietary RPE could modulate the gut microbiota of the H22 bearing mice by increasing the abundance of beneficial bacteria and decreasing that of detrimental bacteria among intestinal bacteria, providing evidence for the mechanism by which bioactive proteins affect intestinal nutrition and disease resistance in animals. |
资助项目 | Strategic Priority Research Program of the Chinese Academy of Sciences[XDA23050302] ; Open Fund of Laboratory for Marine Ecology and Environmental Science, Qingdao National Laboratory for Marine Science and Technology[LMEES201801] ; Open Fund of Qingdao National Laboratory for Marine Science and Technology[QNLM2016ORP0303] |
WOS研究方向 | Pharmacology & Pharmacy |
语种 | 英语 |
出版者 | MDPI |
WOS记录号 | WOS:000507340000017 |
源URL | [http://ir.qdio.ac.cn/handle/337002/164481] |
专题 | 海洋研究所_实验海洋生物学重点实验室 |
通讯作者 | Jiang, Peng; Wang, Dongfeng |
作者单位 | 1.Qingdao Univ, Basic Med Coll, Lab Cell & Mol Biol, Qingdao 266071, Peoples R China 2.Qingdao Univ, Coll Publ Hlth, Dept Human Nutr, Qingdao 266021, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Peoples R China 5.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China 6.Ocean Univ China, Coll Food Sci & Engn, Lab Food Chem & Nutr, Qingdao 266003, Peoples R China 7.Qingdao Univ, Coll Life Sci, Food Sci & Engn Dept, Qingdao 266071, Peoples R China 8.Ocean Univ China, Sch Med & Pharm, Chinese Minist Educ, Key Lab Marine Drugs, Qingdao 266003, Peoples R China |
推荐引用方式 GB/T 7714 | Qi, Hongtao,Liu, Ying,Qi, Xin,et al. Dietary Recombinant Phycoerythrin Modulates the Gut Microbiota of H22 Tumor-Bearing Mice[J]. MARINE DRUGS,2019,17(12):17. |
APA | Qi, Hongtao.,Liu, Ying.,Qi, Xin.,Liang, Hui.,Chen, Huaxin.,...&Wang, Dongfeng.(2019).Dietary Recombinant Phycoerythrin Modulates the Gut Microbiota of H22 Tumor-Bearing Mice.MARINE DRUGS,17(12),17. |
MLA | Qi, Hongtao,et al."Dietary Recombinant Phycoerythrin Modulates the Gut Microbiota of H22 Tumor-Bearing Mice".MARINE DRUGS 17.12(2019):17. |
入库方式: OAI收割
来源:海洋研究所
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