Functional relationship between CgMyD88-1 and CgMyD88-2 in the Pacific oyster
文献类型：期刊论文
| 作者 | Tang, Xueying2,5; Huang, Baoyu1,5,6 ; Lin, Siheng5,6; Wang, Wei1,4,5,6; Zhang, Guofan1,4,5,6; Li, Li1,3,4,5,6
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| 刊名 | FISH & SHELLFISH IMMUNOLOGY
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| 出版日期 | 2020 |
| 卷号 | 96页码:138-140 |
| ISSN号 | 1050-4648 |
| 关键词 | Crassostrea gigas Innate immunity MyD88 Functional diversity |
| DOI | 10.1016/j.fsi.2019.10.060 |
| 通讯作者 | Li, Li(lili@qdio.ac.cn) |
| 英文摘要 | MyD88 is a universal adapter protein for the Toll-like receptor/interleukin-1 receptor (TLR/IL-1R) signaling pathway. Since invertebrates are believed to lack MyD88-independent pathways, MyD88 appears more critical in oyster TLR signaling pathway. In the Pacific oyster (Crassostrea gigas), two complete paralogues, named as CgMyD88-1 and CgMyD88-2, have been identified. In the current study, we indicated that CgMyD88-1 and CgMyD88-2 might act synergistically to increase the efficiency of immune signaling by activating NF-kappa B transcription factor. However, we found that upon stimulation with lipopolysaccharide (LPS) or polyinosinic:polycytidylic acid [poly (I:C)], CgMyD88-1 and CgMyD88-2 show differences in their response: CgMyD88-1 accumulated as large spots in the cytoplasm, while CgMyD88-2 assembled in the cytoplasm and in the membrane. Our results support the theory that expansion of these immune genes is associated with functional diversity. |
| 资助项目 | National Key R&D Program of China[2018YFD0900304] ; Earmarked Fund for China Agricultural Research System[CARS-49] ; Scientific Research Staring Foundation of Minnan normal university[4206-L21829] |
| WOS研究方向 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
| 语种 | 英语 |
| 出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
| WOS记录号 | WOS:000509617400016 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/164484]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 通讯作者 | Li, Li |
| 作者单位 | 1.Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao 266071, Shandong, Peoples R China 2.Minnan Normal Univ, Dept Biol Sci & Biotechnol, Zhangzhou 363000, Fujian, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266071, Shandong, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China 5.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China 6.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266071, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tang, Xueying,Huang, Baoyu,Lin, Siheng,et al. Functional relationship between CgMyD88-1 and CgMyD88-2 in the Pacific oyster[J]. FISH & SHELLFISH IMMUNOLOGY,2020,96:138-140. |
| APA | Tang, Xueying,Huang, Baoyu,Lin, Siheng,Wang, Wei,Zhang, Guofan,&Li, Li.(2020).Functional relationship between CgMyD88-1 and CgMyD88-2 in the Pacific oyster.FISH & SHELLFISH IMMUNOLOGY,96,138-140. |
| MLA | Tang, Xueying,et al."Functional relationship between CgMyD88-1 and CgMyD88-2 in the Pacific oyster".FISH & SHELLFISH IMMUNOLOGY 96(2020):138-140. |
入库方式： OAI收割
来源：海洋研究所
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