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pH-responsive linkages-enabled layer-by-layer assembled antibacterial and antiadhesive multilayer films with polyelectrolyte nanocapsules as biocide delivery vehicles

文献类型：期刊论文

作者Cai, Haoyuan1,2,3,4; Wang, Peng1,2,4; Zhang, Dun1,2,4
刊名JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
出版日期2019-12-01
卷号54页码:15
关键词Antibacterial pH-responsive Layer-by-layer Self-polishing Antiadhesive
ISSN号1773-2247
DOI10.1016/j.jddst.2019.101251
通讯作者Wang, Peng(wangpeng@qdio.ac.cn) ; Zhang, Dun(zhangdun@qdio.ac.cn)
英文摘要Application of the polymer capsules as vehicles for antibacterial surface against bacterial infections is restricted by spontaneous leakage and specifically responsive release of antibacterial agents. Herein, we present the integration of pH-responsive nanocapsules as delivery tools for hydrophobic biocide within layer-by-layer (LbL) films utilizing alternating imine linkages as the driving force for assembly, thus enabling the introduction of drug and controlled release. The novel capsules are fabricated by means of electrostatic LbL assembly, namely, tannin acid/chitosan nanocapsules embedded with triclosan@cetyltrimethylammonium bromide micelles (TCS@CTAB/TA/CH). The nanocapsules achieve an excellent pH-responsive activity that the release efficiency of antibacterial agent triclosan (TCS) increases by nearly 61.8% from pH 8 to 4. Subsequently, the smart nanocapsules are alternatively incorporated via imine linkage into the dextran aldehyde (DA) polyelectrolyte multilayers in LbL deposition (denoted as (DA-TCS@CTAB/TA/CH)(n) films). The as-prepared samples are characterized by FTIR, FESEM, TEM, DLS and AFM. Noticeably, the (DA-TCS @CTAB/TA/CH)(20.5) film exhibites optimal pH-responsive activity with release concentration of TCS up to 4.01 mg/L at pH 6. The bacteriostatic percentages of (DA-TCS@CTAB/TA/CH)(20.5) against E. coll. and P. aeruginosa are respectively 99.62% and 97.35% after 24-h incubation at pH 6. Besides, the multilayers are capable of supplying a long-term (30 days) antibacterial property. The self-polishing mechanism of (DA-TCS@CTAB/TA/CH)(n) films is proposed to illuminate the enhanced antibacterial and antiadhesive performances. It seems that the films present a promising way to incorporate biocide to resist bacterial infections and prolong the antimicrobial activity of antibacterial surface.
资助项目National Natural Science Foundation of China[41576079] ; National Natural Science Foundation of China[41922040] ; Qingdao National Laboratory for Marine Science and Technology[2017ASTCP-ES02] ; AoShan Talent Program
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000505159500080
出版者ELSEVIER
源URL[http://ir.qdio.ac.cn/handle/337002/164106]  
专题海洋研究所_海洋腐蚀与防护研究发展中心
通讯作者Wang, Peng; Zhang, Dun
作者单位1.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Open Studio Marine Corros & Protect, 1 Wenhai Rd, Qingdao 266237, Shandong, Peoples R China
3.Univ Chinese Acad Sci, 19 Jia Yuquan Rd, Beijing 100039, Peoples R China
4.Chinese Acad Sci, Inst Oceanol, Key Lab Marine Environm Corros & Biofouling, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Cai, Haoyuan,Wang, Peng,Zhang, Dun. pH-responsive linkages-enabled layer-by-layer assembled antibacterial and antiadhesive multilayer films with polyelectrolyte nanocapsules as biocide delivery vehicles[J]. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,2019,54:15.
APA Cai, Haoyuan,Wang, Peng,&Zhang, Dun.(2019).pH-responsive linkages-enabled layer-by-layer assembled antibacterial and antiadhesive multilayer films with polyelectrolyte nanocapsules as biocide delivery vehicles.JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY,54,15.
MLA Cai, Haoyuan,et al."pH-responsive linkages-enabled layer-by-layer assembled antibacterial and antiadhesive multilayer films with polyelectrolyte nanocapsules as biocide delivery vehicles".JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY 54(2019):15.

入库方式： OAI收割

来源：海洋研究所

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