中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 自动化研究所
  3. 中国科学院自动化研究所
  4. 中国科学院分子影像重点实验室
Prognostic value of the radiomics-based model in progression-free survival of hypopharyngeal cancer treated with chemoradiation

文献类型：期刊论文

作者Mo, Xiaokai2,3; Wu, Xiangjun1,4; Dong, Di1,4; Guo, Baoliang2; Liang, Changhong2; Luo, Xiaoning2,5; Zhang, Bin6; Zhang, Lu2; Dong, Yuhao2,3; Lian, Zhouyang2
刊名EUROPEAN RADIOLOGY
出版日期2020-02-01
卷号30期号:2页码:833-843
关键词Head and neck cancer Hypopharynx Chemoradiotherapy Recurrence Prognosis
ISSN号0938-7994
DOI10.1007/s00330-019-06452-w
通讯作者Tian, Jie(jie.tian@ia.ac.cn) ; Zhang, Shuixing(shui7515@126.com)
英文摘要Purpose To develop a radiomics-based model to stratify the risk of early progression (local/regional recurrence or metastasis) among patients with hypopharyngeal cancer undergoing chemoradiotherapy and modify their pretreatment plans. Materials and methods We randomly assigned 113 patients into two cohorts: training (n = 80) and validation (n = 33). The radiomic significant features were selected in the training cohort using least absolute shrinkage and selection operator and Akaike information criterion methods, and they were used to build the radiomic model. The concordance index (C-index) was applied to evaluate the model's prognostic performance. A Kaplan-Meier analysis and the log-rank test were used to assess risk stratification ability of models in predicting progression. A nomogram was plotted to predict individual risk of progression. Results Composed of four significant features, the radiomic model showed good performance in stratifying patients into high- and low-risk groups of progression in both the training and validation cohorts (log-rank test, p = 0.00016, p = 0.0063, respectively). Peripheral invasion and metastasis were selected as significant clinical variables. The combined radiomic-clinical model showed good discriminative performance, with C-indices 0.804 (95% confidence interval (CI), 0.688-0.920) and 0.756 (95% CI, 0.605-0.907) in the training and validation cohorts, respectively. The median progression-free survival (PFS) in the high-risk group was significantly shorter than that in the low-risk group in the training (median PFS, 9.5 m and 19.0 m, respectively; p [log-rank] < 0.0001) and validation (median PFS, 11.3 m and 22.5 m, respectively; p [log-rank] = 0.0063) cohorts. Conclusions A radiomics-based model was established to predict the risk of progression in hypopharyngeal cancer with chemoradiotherapy.
WOS关键词LOCALLY ADVANCED HEAD ; TEXTURAL FEATURES ; SALVAGE TREATMENT ; NECK-CANCER ; OROPHARYNGEAL ; CHEMOTHERAPY ; PET ; MANAGEMENT ; TRENDS ; IMAGES
WOS研究方向Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000511977900017
出版者SPRINGER
源URL[http://ir.ia.ac.cn/handle/173211/28574]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Tian, Jie; Zhang, Shuixing
作者单位1.Univ Chinese Acad Sci, Beijing 100190, Peoples R China
2.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Radiol, Guangzhou, Guangdong, Peoples R China
3.Shantou Univ, Coll Med, Shantou, Guangdong, Peoples R China
4.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, 95 Zhongguancun East Rd, Beijing 100190, Peoples R China
5.Guangdong Acad Med Sci, Dept Otolaryngol Head & Neck Surg, Guangdong Prov Peoples Hosp, Guangzhou, Guangdong, Peoples R China
6.Jinan Univ, Affiliated Hosp 1, Dept Radiol, 613 Huangpu West Rd, Guangzhou 510627, Guangdong, Peoples R China
7.Beihang Univ, Sch Med, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714		 Mo, Xiaokai,Wu, Xiangjun,Dong, Di,et al. Prognostic value of the radiomics-based model in progression-free survival of hypopharyngeal cancer treated with chemoradiation[J]. EUROPEAN RADIOLOGY,2020,30(2):833-843.
APA Mo, Xiaokai.,Wu, Xiangjun.,Dong, Di.,Guo, Baoliang.,Liang, Changhong.,...&Zhang, Shuixing.(2020).Prognostic value of the radiomics-based model in progression-free survival of hypopharyngeal cancer treated with chemoradiation.EUROPEAN RADIOLOGY,30(2),833-843.
MLA Mo, Xiaokai,et al."Prognostic value of the radiomics-based model in progression-free survival of hypopharyngeal cancer treated with chemoradiation".EUROPEAN RADIOLOGY 30.2(2020):833-843.

入库方式： OAI收割

来源：自动化研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。