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A radiomics-based biomarker for cytokeratin 19 status of hepatocellular carcinoma with gadoxetic acid-enhanced MRI

文献类型：期刊论文

作者Wang, Wentao2,3; Gu, Dongsheng4,5; Wei, Jingwei4,5; Ding, Ying2,3; Yang, Li2,3; Zhu, Kai6; Luo, Rongkui7; Rao, Sheng-Xiang2,3; Tian, Jie1,4,5,8; Zeng, Mengsu2,3
刊名EUROPEAN RADIOLOGY
出版日期2020-01-30
页码11
关键词Diagnosis Cytokeratin 19 Hepatocellular carcinoma
ISSN号0938-7994
DOI10.1007/s00330-019-06585-y
通讯作者Tian, Jie(tian@ieee.org) ; Zeng, Mengsu(zengmengsu@outlook.com)
英文摘要Objectives We aimed to develop a radiomics-based model derived from gadoxetic acid-enhanced MR images to preoperatively identify cytokeratin (CK) 19 status of hepatocellular carcinoma (HCC). Methods A cohort of 227 patients with single HCC was classified into a training set (n = 159) and a time-independent validated set (n = 68). A total of 647 radiomic features were extracted from multi-sequence MR images. The least absolute shrinkage and selection operator regression and decision tree methods were utilized for feature selection and radiomics signature construction. A multivariable logistic regression model incorporating clinico-radiological features and the fusion radiomics signature was built for prediction of CK19 status by evaluating area under curve (AUC). Results In the whole cohort, 57 patients were CK19 positive and 170 patients were CK19 negative. By combining 11 and 6 radiomic features extracted in arterial phase and hepatobiliary phase images, respectively, a fusion radiomics signature achieved AUCs of 0.951 and 0.822 in training and validation datasets. The final combined model integrated a-fetoprotein levels, arterial rim enhancement pattern, irregular tumor margin, and the fusion radiomics signature, with a sensitivity of 0.818 and specificity of 0.974 in the training cohort and that of 0.769 and 0.818 in the validated cohort. The nomogram based on the combined model showed satisfactory prediction performance in training (C-index 0.959) and validation (C-index 0.846) dataset. Conclusions The combined model based on a fusion radiomics signature derived from arterial and hepatobiliary phase images of gadoxetic acid-enhanced MRI can be a reliable biomarker for CK19 status of HCC.
WOS关键词LIVER-CANCER ; EXPRESSION ; PROGNOSIS ; MARKERS ; CLASSIFICATION ; FEATURES ; DISTINCT ; CELLS
资助项目National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81571661] ; Chinese Academy of Sciences[GJJSTD20170004] ; Shanghai Sailing Program[19YF1408100]
WOS研究方向Radiology, Nuclear Medicine & Medical Imaging
语种英语
WOS记录号WOS:000510295000003
出版者SPRINGER
资助机构National Natural Science Foundation of China ; Chinese Academy of Sciences ; Shanghai Sailing Program
源URL[http://ir.ia.ac.cn/handle/173211/28576]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Tian, Jie; Zeng, Mengsu
作者单位1.Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Sch Life Sci & Technol, Xian 710126, Shaanxi, Peoples R China
2.Fudan Univ, Shanghai Med Imaging Inst, 180 Fenglin Rd, Shanghai 200032, Peoples R China
3.Fudan Univ, Dept Radiol, Zhongshan Hosp, 180 Fenglin Rd, Shanghai 200032, Peoples R China
4.Chinese Acad Sci, Key Lab Mol Imaging, Inst Automat, 95 Zhongguancun East Rd, Beijing 100190, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Fudan Univ, Liver Canc Inst, Zhongshan Hosp, Shanghai, Peoples R China
7.Fudan Univ, Zhongshan Hosp, Dept Pathol, Shanghai, Peoples R China
8.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Wentao,Gu, Dongsheng,Wei, Jingwei,et al. A radiomics-based biomarker for cytokeratin 19 status of hepatocellular carcinoma with gadoxetic acid-enhanced MRI[J]. EUROPEAN RADIOLOGY,2020:11.
APA Wang, Wentao.,Gu, Dongsheng.,Wei, Jingwei.,Ding, Ying.,Yang, Li.,...&Zeng, Mengsu.(2020).A radiomics-based biomarker for cytokeratin 19 status of hepatocellular carcinoma with gadoxetic acid-enhanced MRI.EUROPEAN RADIOLOGY,11.
MLA Wang, Wentao,et al."A radiomics-based biomarker for cytokeratin 19 status of hepatocellular carcinoma with gadoxetic acid-enhanced MRI".EUROPEAN RADIOLOGY (2020):11.

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来源：自动化研究所

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