A common hub for sleep and motor control in the substantia nigra
文献类型：期刊论文
| 作者 | Liu, Danqian2; Li, Weifu1; Ma, Chenyan2; Zheng, Weitong2; Yao, Yuanyuan2; Tso, Chak Foon2; Zhong, Peng2; Chen, Xi1 ; Song, Jun Ho3; Choi, Woochul3
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| 刊名 | SCIENCE
 |
| 出版日期 | 2020-01-24 |
| 卷号 | 367期号:6476页码:440-+ |
| ISSN号 | 0036-8075 |
| DOI | 10.1126/science.aaz0956 |
| 通讯作者 | Dan, Yang(ydan@berkeley.edu) |
| 英文摘要 | The arousal state of the brain covaries with the motor state of the animal. How these state changes are coordinated remains unclear. We discovered that sleep-wake brain states and motor behaviors are coregulated by shared neurons in the substantia nigra pars reticulata (SNr). Analysis of mouse home-cage behavior identified four states with different levels of brain arousal and motor activity: locomotion, nonlocomotor movement, quiet wakefulness, and sleep; transitions occurred not randomly but primarily between neighboring states. The glutamic acid decarboxylase 2 but not the parvalbumin subset of SNr gamma-aminobutyric acid (GABA)-releasing (GABAergic) neurons was preferentially active in states of low motor activity and arousal. Their activation or inactivation biased the direction of natural behavioral transitions and promoted or suppressed sleep, respectively. These GABAergic neurons integrate wide-ranging inputs and innervate multiple arousal-promoting and motor-control circuits through extensive collateral projections. |
| WOS关键词 | GABAERGIC NEURONS ; CIRCUITS ; ORGANIZATION ; DROSOPHILA ; PATHWAYS ; MIDBRAIN ; BEHAVIOR ; INPUTS ; GABA |
| 资助项目 | Howard Hughes Medical Institute |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| WOS记录号 | WOS:000509810200041 |
| 资助机构 | Howard Hughes Medical Institute |
| 源URL | [http://ir.ia.ac.cn/handle/173211/28592]  |
| 专题 | 类脑智能研究中心_微观重建与智能分析 |
| 通讯作者 | Dan, Yang |
| 作者单位 | 1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China 2.Univ Calif Berkeley, Howard Hughes Med Inst, Helen Wills Neurosci Inst, Div Neurobiol,Dept Mol & Cell Biol, Berkeley, CA 94720 USA 3.Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Daejeon 34141, South Korea |
| 推荐引用方式 GB/T 7714 | Liu, Danqian,Li, Weifu,Ma, Chenyan,et al. A common hub for sleep and motor control in the substantia nigra[J]. SCIENCE,2020,367(6476):440-+. |
| APA | Liu, Danqian.,Li, Weifu.,Ma, Chenyan.,Zheng, Weitong.,Yao, Yuanyuan.,...&Dan, Yang.(2020).A common hub for sleep and motor control in the substantia nigra.SCIENCE,367(6476),440-+. |
| MLA | Liu, Danqian,et al."A common hub for sleep and motor control in the substantia nigra".SCIENCE 367.6476(2020):440-+. |
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