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Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer

文献类型：期刊论文

作者You, Huijuan2,3; Shang, Wenting3; Min, Xiangde2; Weinreb, Jeffrey4; Li, Qiubai5; Leapman, Michael1; Wang, Liang2; Tian, Jie3,6
刊名SCIENCE ADVANCES
出版日期2020-02-01
卷号6期号:6页码:14
ISSN号2375-2548
DOI10.1126/sciadv.aax6040
通讯作者Shang, Wenting(wenting.shang@ia.ac.cn) ; Wang, Liang(wang6@tjh.tjmu.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
英文摘要Nerve density is associated with prostate cancer (PCa) aggressiveness and prognosis. Thus far, no visualization methods have been developed to assess nerve density of PCa in vivo. We compounded propranolol-conjugated superparamagnetic iron oxide nerve peptide nanoparticles (PSN NPs), which achieved the nerve density visualization of PCa with high sensitivity and high specificity, and facilitated assessment of nerve density and aggressiveness of PCa using magnetic resonance imaging and magnetic particle imaging. Moreover, PSN NPs facilitated targeted therapy for PCa. PSN NPs increased the survival rate of mice with orthotopic PCa to 83.3% and decreased nerve densities and proliferation indexes by more than twofold compared with the control groups. The present study, thus, developed a technology to visualize the nerve density of PCa and facilitate targeted neural drug delivery to tumors to efficiently inhibit PCa progression. Our study provides a potential basis for clinical imaging and therapeutic interventions targeting nerves in PCa.
WOS关键词ESTRO-SIOG GUIDELINES ; SUPERPARAMAGNETIC NANOPARTICLES ; RAT ; SENSITIVITY ; RESOLUTION ; PROBES
资助项目National Key R&D Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81671656] ; National Natural Science Foundation of China[81801668] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81501540] ; Ministry of Science and Technology of China[2017YFA0700401] ; Chinese Academy of Sciences[GJJSTD20170004] ; Chinese Academy of Sciences[YJKYYQ20170075] ; Chinese Academy of Sciences[XDBS01030200]
WOS研究方向Science & Technology - Other Topics
语种英语
出版者AMER ASSOC ADVANCEMENT SCIENCE
WOS记录号WOS:000512902300010
资助机构National Key R&D Program of China ; National Natural Science Foundation of China ; Ministry of Science and Technology of China ; Chinese Academy of Sciences
源URL[http://ir.ia.ac.cn/handle/173211/28596]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Shang, Wenting; Wang, Liang; Tian, Jie
作者单位1.Yale Univ, Sch Med, Dept Urol, New Haven, CT 06520 USA
2.Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Radiol, Tongji Hosp, Wuhan 430030, Hubei, Peoples R China
3.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Yale Univ, Sch Med, Dept Radiol & Biomed Imaging, New Haven, CT 06520 USA
5.UT Southwestern Med Ctr, Dept Radiol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA
6.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714		 You, Huijuan,Shang, Wenting,Min, Xiangde,et al. Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer[J]. SCIENCE ADVANCES,2020,6(6):14.
APA You, Huijuan.,Shang, Wenting.,Min, Xiangde.,Weinreb, Jeffrey.,Li, Qiubai.,...&Tian, Jie.(2020).Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer.SCIENCE ADVANCES,6(6),14.
MLA You, Huijuan,et al."Sight and switch off: Nerve density visualization for interventions targeting nerves in prostate cancer".SCIENCE ADVANCES 6.6(2020):14.

入库方式： OAI收割

来源：自动化研究所

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