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A new method of near-infrared fluorescence image-guided hepatectomy for patients with hepatolithiasis: a randomized controlled trial

文献类型：期刊论文

作者He, Kunshan1,3; Hong, Xiaopeng1; Chi, Chongwei2; Cai, Chaonong1; Wang, Kun2; Li, Peiping1; Liu, Xialei1; Li, Jian1; Shan, Hong1; Tian, Jie2,3
刊名SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
出版日期2020-02-04
页码8
关键词Near-infrared fluorescence Fluorescence image-guided hepatectomy Hepatolithiasis Indocyanine green Intraoperative imaging
ISSN号0930-2794
DOI10.1007/s00464-019-07290-z
通讯作者Li, Jian(lijian5@mail.sysu.edu.cn) ; Shan, Hong(shanhong@mail.sysu.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
英文摘要Background Hepatectomy is a definitive treatment for hepatolithiasis because it simultaneously removes intrahepatic duct (IHD) stones and biliary tract strictures together with the involved liver region en bloc. Unlike cystic or solid liver tumors, hepatolithiasis is usually associated with alterations of anatomical structures and perihepatic adhesions because of chronic recurrent inflammation. This complicates identification of the target hepatic region and location of biliary strictures. Methods To determine the efficacy of near-infrared fluorescence (NIRF) imaging using indocyanine green (ICG), we performed a comparative trial and developed a white-light and near-infrared dual-channel image-guided device (DPM-I) for both open and endoscopic surgery. Forty-four eligible patients were randomly assigned to Group A (NIRF imaging) or Group B (traditional hepatectomy). We injected ICG via peripheral veins for patients in Group A. Results The NIRF imaging method was associated with less blood loss (OR 1.004, 95% CI 0.999-1.010; P = 0.016), briefer hospitalization (OR 1.336, 95% CI 1.016-1.756; P = 0.001), lower rates of margins with dilated bile ducts (OR 1.278, 95% CI 1.030-1.585; P = 0.023), lower postoperative white blood cell counts (OR 1.262, 95% CI 0.931-1.712; P = 0.038), lower procalcitonin levels (OR 1.316, 95% CI 1.020-1.513; P = 0.002), and lower alanine aminotransferase levels (OR 1.013, 95% CI 1.003-1.023; P = 0.002) compared with traditional hepatectomy. Conclusions These data demonstrate the efficacy of NIRF imaging with ICG using DPM-I for treating hepatolithiasis.
WOS关键词INDOCYANINE GREEN FLUORESCENCE ; LYMPH-NODE BIOPSY ; LAPAROSCOPIC APPROACH ; BREAST-CANCER ; RESECTION ; LITHOTOMY ; SURGERY
资助项目Ministry of Science and Technology of the People's Republic of China (MOST)[2017YFA0205200] ; Ministry of Science and Technology of the People's Republic of China (MOST)[2017YFA0700401] ; Ministry of Science and Technology of the People's Republic of China (MOST)[2016YFA0100902] ; Ministry of Science and Technology of the People's Republic of China (MOST)[2019YFC0120800] ; National Natural Science Foundation of China (NSFC)[81527805] ; National Natural Science Foundation of China (NSFC)[81971773] ; Key Research Projects in Frontier Science of Chinese Academy of Sciences (CAS)[QYZDJ-SSW-JSC005] ; Key Research Projects in Frontier Science of Chinese Academy of Sciences (CAS)[KFJ-STS-ZDTP-059] ; Natural Science Foundation of Guangdong Province of China[2018A0303130292] ; Natural Science Foundation of Guangdong Province of China[2019A1515011356] ; Project of Administration of Traditional Chinese Medicine of Guangdong Province of China[20181062] ; China Postdoctoral Science Foundation[2019M660409]
WOS研究方向Surgery
语种英语
WOS记录号WOS:000511080200001
出版者SPRINGER
资助机构Ministry of Science and Technology of the People's Republic of China (MOST) ; National Natural Science Foundation of China (NSFC) ; Key Research Projects in Frontier Science of Chinese Academy of Sciences (CAS) ; Natural Science Foundation of Guangdong Province of China ; Project of Administration of Traditional Chinese Medicine of Guangdong Province of China ; China Postdoctoral Science Foundation
源URL[http://ir.ia.ac.cn/handle/173211/28616]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Li, Jian; Shan, Hong; Tian, Jie
作者单位1.Sun Yat Sen Univ, Affiliated Hosp 5, Zhuhai, Peoples R China
2.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med & Engn, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714		 He, Kunshan,Hong, Xiaopeng,Chi, Chongwei,et al. A new method of near-infrared fluorescence image-guided hepatectomy for patients with hepatolithiasis: a randomized controlled trial[J]. SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES,2020:8.
APA He, Kunshan.,Hong, Xiaopeng.,Chi, Chongwei.,Cai, Chaonong.,Wang, Kun.,...&Tian, Jie.(2020).A new method of near-infrared fluorescence image-guided hepatectomy for patients with hepatolithiasis: a randomized controlled trial.SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES,8.
MLA He, Kunshan,et al."A new method of near-infrared fluorescence image-guided hepatectomy for patients with hepatolithiasis: a randomized controlled trial".SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES (2020):8.

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