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Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients

文献类型：期刊论文

作者Lin, Yuan3,4; Li, Lin-Lin1; Nie, Wei3; Liu, Xiaolei2; Adler, Avital4; Xiao, Chi1; Lu, Fujian3; Wang, Liping2; Han, Hua1; Wang, Xianhua3
刊名NATURE COMMUNICATIONS
出版日期2019-11-21
卷号10页码:13
ISSN号2041-1723
DOI10.1038/s41467-019-13142-0
通讯作者Gan, Wen-Biao(Wenbiao.Gan@nyulangone.org) ; Cheng, Heping(chengp@pku.edu.cn)
英文摘要Mitochondrial calcium ([Ca2+](mito)) dynamics plays vital roles in regulating fundamental cellular and organellar functions including bioenergetics. However, neuronal [Ca2+](mito) dynamics in vivo and its regulation by brain activity are largely unknown. By performing twophoton Ca2+ imaging in the primary motor (M1) and visual cortexes (V1) of awake behaving mice, we find that discrete [Ca2+](mito) transients occur synchronously over somatic and dendritic mitochondrial network, and couple with cytosolic calcium ([Ca2+](cyto)) transients in a probabilistic, rather than deterministic manner. The amplitude, duration, and frequency of [Ca2+](cyto) transients constitute important determinants of the coupling, and the coupling fidelity is greatly increased during treadmill running (in M1 neurons) and visual stimulation (in V1 neurons). Moreover, Ca2+/calmodulin kinase II is mechanistically involved in modulating the dynamic coupling process. Thus, activity-dependent dynamic [Ca2+](mito)-to[Ca2+] cyto coupling affords an important mechanism whereby [Ca2+](mito) decodes brain activity for the regulation of mitochondrial bioenergetics to meet fluctuating neuronal energy demands as well as for neuronal information processing.
WOS关键词PROTEIN-KINASE-II ; ESSENTIAL COMPONENT ; DENDRITIC SPINES ; MOTOR CORTEX ; CALCIUM ; DYSFUNCTION ; FREQUENCY ; DYNAMICS ; DISEASE ; ER
资助项目National Key Basic Research Program of China[2017YFA0504000] ; National Key Basic Research Program of China[2016YFA0500403] ; National Science Foundation of China[31670039] ; National Science Foundation of China[31970058] ; National Science Foundation of China[8182780030] ; National Science Foundation of China[31821091] ; NIH[5R01NS087198] ; NIH[5R01NS047325] ; NIH[1R21AG061751]
WOS研究方向Science & Technology - Other Topics
语种英语
出版者NATURE PUBLISHING GROUP
WOS记录号WOS:000497699100010
资助机构National Key Basic Research Program of China ; National Science Foundation of China ; NIH
源URL[http://ir.ia.ac.cn/handle/173211/29343]  
专题类脑智能研究中心_微观重建与智能分析
中国科学院自动化研究所
通讯作者Gan, Wen-Biao; Cheng, Heping
作者单位1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Shenzhen Inst Adv Technol, Brain Cognit & Brain Dis Inst, Shenzhen 518055, Guangdong, Peoples R China
3.Peking Univ, Beijing Key Lab Cardiometab Mol Med, Peking Tsinghua Ctr Life Sci, State Key Lab Membrane Biol,Inst Mol Med, Beijing 100871, Peoples R China
4.NYU, Sch Med, Skirball Inst Biomol Med,Neurosci Inst, Dept Neurosci & Physiol,Dept Anesthesiol, New York, NY 10016 USA
推荐引用方式
GB/T 7714		 Lin, Yuan,Li, Lin-Lin,Nie, Wei,et al. Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients[J]. NATURE COMMUNICATIONS,2019,10:13.
APA Lin, Yuan.,Li, Lin-Lin.,Nie, Wei.,Liu, Xiaolei.,Adler, Avital.,...&Cheng, Heping.(2019).Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients.NATURE COMMUNICATIONS,10,13.
MLA Lin, Yuan,et al."Brain activity regulates loose coupling between mitochondrial and cytosolic Ca2+ transients".NATURE COMMUNICATIONS 10(2019):13.

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来源：自动化研究所

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