Theranostic liposomes as nanodelivered chemotherapeutics enhanced the microwave ablation of hepatocellular carcinoma
文献类型：期刊论文
| 作者 | Zhou, Qunfang1,4; Wang, Kun4 ; Dou, Jianping1; Cao, Feng3; Liu, Fengyong2; Yuan, Hongjun2; Mu, Mengjuan1; Xu, Jinshun1; Zhang, Dongyun1; Li, Xin1
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| 刊名 | NANOMEDICINE
 |
| 出版日期 | 2019-08-01 |
| 卷号 | 14期号:16页码:2151-2167 |
| 关键词 | hepatocellular carcinoma liposomes microwave ablation optoacoustic tomography imaging theranostics |
| ISSN号 | 1743-5889 |
| DOI | 10.2217/nnm-2018-0424 |
| 通讯作者 | Tian, Jie(jie.tian@ia.ac.cn) ; Yu, Jie(jiemi301@163.com) ; Liang, Ping(liangping301@hotmail.com) |
| 英文摘要 | Aim: This study aimed to develop indocyanine green- and doxorubicin-loaded liposomes (DILPs) as theranostic nanoplatform for the detection of hepatocellular carcinoma (HCC) and as an efficient chemotherapeutic to enhance microwave ablation. Materials & methods: DILPs were synthesized and thoroughly characterized. Biocompatibility, tumor uptake and accumulation, and synergistic ablation-chemotherapeutic efficiency were systematically explored in them. In addition, human HCC surgical samples were used to test the affinity of DILPs for HCC. Results: The combination of microwave ablation and DILPs enhanced the ablation efficiency of HCC with apparent tumor inhibition. DILPs exhibited excellent diagnostic ability and could detect 2.5-mm HCC lesions via optoacoustic tomography imaging. DILPs had better affinity for human HCC surgical samples compared with normal liver tissue. Conclusion: Theranostic DILPs could serve as promising nanoparticles for treatment and management of HCC in the clinic. |
| WOS关键词 | RADIOFREQUENCY ABLATION ; TUMOR ; NANOPARTICLES ; DOXORUBICIN ; CANCER ; MULTICENTER ; SURVIVAL ; RECURRENCE ; EFFICACY ; THERAPY |
| 资助项目 | National Natural Science Foundation of China[81622024] ; National Key R&D Program of China[2017YFC0112000] ; Postdoctoral Science Foundation of China[2017M613327] |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000498812800004 |
| 出版者 | FUTURE MEDICINE LTD |
| 资助机构 | National Natural Science Foundation of China ; National Key R&D Program of China ; Postdoctoral Science Foundation of China |
| 源URL | [http://ir.ia.ac.cn/handle/173211/29397]  |
| 专题 | 自动化研究所_中国科学院分子影像重点实验室 |
| 通讯作者 | Tian, Jie; Yu, Jie; Liang, Ping |
| 作者单位 | 1.Chinese Peoples Liberat Army Gen Hosp, Dept Intervent Ultrasound, Beijing 100853, Peoples R China 2.Chinese Peoples Liberat Army Gen Hosp, Dept Intervent Radiol, Beijing 100853, Peoples R China 3.Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China 4.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Qunfang,Wang, Kun,Dou, Jianping,et al. Theranostic liposomes as nanodelivered chemotherapeutics enhanced the microwave ablation of hepatocellular carcinoma[J]. NANOMEDICINE,2019,14(16):2151-2167. |
| APA | Zhou, Qunfang.,Wang, Kun.,Dou, Jianping.,Cao, Feng.,Liu, Fengyong.,...&Liang, Ping.(2019).Theranostic liposomes as nanodelivered chemotherapeutics enhanced the microwave ablation of hepatocellular carcinoma.NANOMEDICINE,14(16),2151-2167. |
| MLA | Zhou, Qunfang,et al."Theranostic liposomes as nanodelivered chemotherapeutics enhanced the microwave ablation of hepatocellular carcinoma".NANOMEDICINE 14.16(2019):2151-2167. |
入库方式： OAI收割
来源：自动化研究所
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