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Electroconvulsive therapy treatment responsive multimodal brain networks

文献类型：期刊论文

作者Qi, Shile7; Abbott, Christopher C.8; Narr, Katherine L.9; Jiang, Rongtao1,5,6; Upston, Joel8; McClintock, Shawn M.4; Espinoza, Randall9; Jones, Tom8; Zhi, Dongmei1,5,6; Sun, Hailun1,5,6
刊名HUMAN BRAIN MAPPING
出版日期2020-01-06
页码11
ISSN号1065-9471
关键词depressive episodes electroconvulsive therapy multimodal fusion treatment response
DOI10.1002/hbm.24910
通讯作者Abbott, Christopher C.(cabbott@salud.unm.edu) ; Sui, Jing(kittysj@gmail.com)
英文摘要Electroconvulsive therapy is regarded as the most effective antidepressant treatment for severe and treatment-resistant depressive episodes. Despite the efficacy of electroconvulsive therapy, the neurobiological underpinnings and mechanisms underlying electroconvulsive therapy induced antidepressant effects remain unclear. The objective of this investigation was to identify electroconvulsive therapy treatment responsive multimodal biomarkers with the 17-item Hamilton Depression Rating Scale guided brain structure-function fusion in 118 patients with depressive episodes and 60 healthy controls. Results show that reduced fractional amplitude of low frequency fluctuations in the prefrontal cortex, insula and hippocampus, linked with increased gray matter volume in anterior cingulate, medial temporal cortex, insula, thalamus, caudate and hippocampus represent electroconvulsive therapy responsive covarying functional and structural brain networks. In addition, relative to nonresponders, responder-specific electroconvulsive therapy related brain networks occur in frontal-limbic network and are associated with successful therapeutic outcomes. Finally, electroconvulsive therapy responsive brain networks were unrelated to verbal declarative memory. Using a data-driven, supervised-learning method, we demonstrated that electroconvulsive therapy produces a remodeling of brain functional and structural covariance that was unique to antidepressant symptom response, but not linked to memory impairment.
WOS关键词MAJOR DEPRESSION ; SUBSEQUENT ; ECT ; PHARMACOTHERAPY ; CONSORTIUM ; PREDICTION ; REMISSION ; DIAGNOSIS ; RBANS
资助项目Beijing Municipal Science and Technology Commission[Z181100001518005] ; China Natural Science Foundation[61773380] ; National Institute of Health[1R01EB005846] ; National Institute of Health[1R01MH094524] ; National Institute of Health[1R56MH117107] ; National Institute of Health[P20GM103472] ; National Institute of Health[P30GM122734] ; National Institute of Health[R01EB020407] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDBS03040100] ; National Institute of Mental Health[U01MH111826] ; National Science Foundation[1539067]
WOS研究方向Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
语种英语
出版者WILEY
WOS记录号WOS:000505639000001
资助机构Beijing Municipal Science and Technology Commission ; China Natural Science Foundation ; National Institute of Health ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Institute of Mental Health ; National Science Foundation
源URL[http://ir.ia.ac.cn/handle/173211/29471]  
专题自动化研究所_脑网络组研究中心
通讯作者Abbott, Christopher C.; Sui, Jing
作者单位1.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China
2.Chinese Acad Sci, Ctr Excellence Brain Sci, Inst Automat, Beijing, Peoples R China
3.Sichuan Univ, West China Hosp, Huaxi Brain Res Ctr, Chengdu, Sichuan, Peoples R China
4.Univ Texas Southwestern Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA
5.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China
6.Univ Chinese Acad Sci, Beijing, Peoples R China
7.Emory Univ, Georgia State Univ, Georgia Inst Technol, Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA 30322 USA
8.Univ New Mexico, Dept Psychiat, Albuquerque, NM 87131 USA
9.Univ Calif Los Angeles, Dept Neurol Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA
推荐引用方式
GB/T 7714		 Qi, Shile,Abbott, Christopher C.,Narr, Katherine L.,et al. Electroconvulsive therapy treatment responsive multimodal brain networks[J]. HUMAN BRAIN MAPPING,2020:11.
APA Qi, Shile.,Abbott, Christopher C..,Narr, Katherine L..,Jiang, Rongtao.,Upston, Joel.,...&Calhoun, Vince D..(2020).Electroconvulsive therapy treatment responsive multimodal brain networks.HUMAN BRAIN MAPPING,11.
MLA Qi, Shile,et al."Electroconvulsive therapy treatment responsive multimodal brain networks".HUMAN BRAIN MAPPING (2020):11.

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来源：自动化研究所

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