中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 自动化研究所
  3. 中国科学院自动化研究所
  4. 中国科学院分子影像重点实验室
Metal-Organic Frameworks as a Theranostic Nanoplatform for Combinatorial Chemophotothermal Therapy Adapted to Different Administration

文献类型：期刊论文

作者Shang, Wenting2,3; Peng, Li1; Guo, Pengyu1; Hui, Hui2,3; Yang, Xin2,3; Tian, Jie2,3,4
刊名ACS BIOMATERIALS SCIENCE & ENGINEERING
出版日期2020-02-01
卷号6期号:2页码:1008-1016
关键词metal-organic frameworks (MOFs) intravenous injection local instillation photothermal therapy combination therapy
ISSN号2373-9878
DOI10.1021/acsbiomaterials.9b01075
通讯作者Hui, Hui(hui.hui@ia.ac.cn) ; Yang, Xin(xin.yang@ia.ac.cn) ; Tian, Jie(jie.tian@ia.ac.cn)
英文摘要With the rapid development of nanotechnology, nanomaterial drug delivery systems have provided an alternative for designing controllable drug delivery systems due to their spatiotemporally controllable properties. As a new type of porous material, metal organic frameworks (MOFs) have been widely used in biomedical applications, especially drug delivery systems, owing to their tunable pore size, high surface area and pore volume, and easy surface modification. Here, we demonstrate an MOF as a theranostic nanoplatform to combine drug therapy and phototherapy after labeling targeting peptide iRGD. The micropore Fe-MOF was used as MRI agents for locating tumors and as nanocarriers to upload chemotherapeutic drugs. Moreover, MOF showed excellent targeting performance under different administration including intravenous injection for breast cancer and local instillation for bladder cancer. Notably, when irradiated with an 808 nm laser, the agent demonstrates the high efficacy of photothermal therapy and heat release efficiency of the drug around the tumor site. This combination therapy provides an alternative drug administration method and can be adapted to a series of cancer cell types and molecular targets associated with disease progression.
WOS关键词DELIVERY SYSTEMS ; DRUG ; CANCER ; CONJUGATE ; DIAGNOSIS ; DESIGN ; AGENTS
资助项目National Key R&D Program of China[2017YFA0205200] ; National Key R&D Program of China[2017YFA0700401] ; National Key R&D Program of China[2017YFA0205203] ; National Key R&D Program of China[2016YFC0103803] ; National Natural Science Foundation of China[81227901] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81671851] ; Chinese Academy of Sciences[GJJSTD20170004] ; Chinese Academy of Sciences[YJKYYQ20170075] ; CAS[XDBS01030200]
WOS研究方向Materials Science
语种英语
WOS记录号WOS:000513086900021
出版者AMER CHEMICAL SOC
资助机构National Key R&D Program of China ; National Natural Science Foundation of China ; Chinese Academy of Sciences ; CAS
源URL[http://ir.ia.ac.cn/handle/173211/38355]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Hui, Hui; Yang, Xin; Tian, Jie
作者单位1.Harbin Med Univ, Hosp 4, Urinary Surg Dept, Haerbin 150001, Peoples R China
2.Chinese Acad Sci, Inst Automat, State Key Lab Management & Control Complex Syst, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
3.Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China
4.Beihang Univ, Sch Med, Beijing Adv Innovat Ctr Big Data Based Precis Med, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714		 Shang, Wenting,Peng, Li,Guo, Pengyu,et al. Metal-Organic Frameworks as a Theranostic Nanoplatform for Combinatorial Chemophotothermal Therapy Adapted to Different Administration[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2020,6(2):1008-1016.
APA Shang, Wenting,Peng, Li,Guo, Pengyu,Hui, Hui,Yang, Xin,&Tian, Jie.(2020).Metal-Organic Frameworks as a Theranostic Nanoplatform for Combinatorial Chemophotothermal Therapy Adapted to Different Administration.ACS BIOMATERIALS SCIENCE & ENGINEERING,6(2),1008-1016.
MLA Shang, Wenting,et al."Metal-Organic Frameworks as a Theranostic Nanoplatform for Combinatorial Chemophotothermal Therapy Adapted to Different Administration".ACS BIOMATERIALS SCIENCE & ENGINEERING 6.2(2020):1008-1016.

入库方式： OAI收割

来源：自动化研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。