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Artificially Engineered Cubic Iron Oxide Nanoparticle as a High-Performance Magnetic Particle Imaging Tracer for Stem Cell Tracking

文献类型：期刊论文

作者Wang, Qiyue3; Ma, Xibo1,2,5; Liao, Hongwei3; Liang, Zeyu3; Li, Fangyuan3,4; Tian, Jie5,6; Ling, Daishun4,7
刊名ACS NANO
出版日期2020-02-01
卷号14期号:2页码:2053-2062
关键词magnetic particle imaging cubic iron oxide nanoparticle bone mesenchymal stem cell stem cell tracking hindlimb ischemia
ISSN号1936-0851
DOI10.1021/acsnano.9b08660
通讯作者Li, Fangyuan(lfy@zju.edu.cn) ; Tian, Jie(jie.tian@ia.ac.cn) ; Ling, Daishun(lingds@zju.edu.cn)
英文摘要Stem cell therapies are increasingly recognized as the future direction of regenerative medicine, but the biological fate of the administrated stem cells remains a major concern for clinical translation, which calls for an approach to efficiently monitoring the stem cell behaviors in vivo. Magnetic particle imaging (MPI) is an emerging technology for cell tracking; however, its utility has been largely restricted due to the lack of optimal magnetic nanoparticle tracers. Herein, by controlled engineering of the size and shape of magnetic nanoparticles tailored to MPI physics theory, a specialized MPI tracer, based on cubic iron oxide nanoparticles with an edge length of 22 nm (CIONs-22), is developed. Due to the inherent lower proportion of disordered surface spins, CIONs-22 exhibit significantly larger saturation magnetization than that of spherical ones, while they possess similar saturation magnetization but smaller coercivity compared to larger-sized CIONs. These magnetic properties of CIONs-22 warrant high sensitivity and resolution of MPI. With their efficient cellular uptake, CIONs-22 exhibit superior MPI performance for stem cell labeling and tracking compared to the commercialized tracer Vivotrax. By virtue of these advantages, CIONs-22 enable real-time and prolonged monitoring of the spatiotemporal trajectory of stem cells transplanted to hindlimb ischemia mice, which demonstrates the great potential of CIONs-22 as MPI tracers to advance stem cell therapies.
WOS关键词TRANSPLANTATION ; DELIVERY ; SURFACE
资助项目National Key Research and Development Program of China[2016YFA0203600] ; National Key Research and Development Program of China[2017YFA0205200] ; National Key Research and Development Program of China[2016YFA0100902] ; National Natural Science Foundation of China[31822019] ; National Natural Science Foundation of China[51703195] ; National Natural Science Foundation of China[91859116] ; National Natural Science Foundation of China[81871442] ; National Natural Science Foundation of China[61876178] ; One Belt and One Road International Cooperation Project from the Key Research and Development Program of Zhejiang Province[2019C04024] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002] ; Fundamental Research Funds for the Central Universities[2019XZZX004IS] ; Zhejiang Provincial Natural Science Foundation of China[LGF19C100002]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000518024700073
出版者AMER CHEMICAL SOC
资助机构National Key Research and Development Program of China ; National Natural Science Foundation of China ; One Belt and One Road International Cooperation Project from the Key Research and Development Program of Zhejiang Province ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China ; Fundamental Research Funds for the Central Universities ; Zhejiang Provincial Natural Science Foundation of China
源URL[http://ir.ia.ac.cn/handle/173211/38407]  
专题自动化研究所_中国科学院分子影像重点实验室
通讯作者Li, Fangyuan; Tian, Jie; Ling, Daishun
作者单位1.Chinese Acad Sci, Inst Automat, CBSR, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Inst Automat, NLPR, Beijing 100190, Peoples R China
3.Zhejiang Univ, Coll Pharmaceut Sci, Inst Pharmaceut, Hangzhou 310058, Zhejiang, Peoples R China
4.Zhejiang Univ, Coll Pharmaceut Sci, Zhejiang Prov Key Lab Anticanc Drug Res, Hangzhou 310058, Zhejiang, Peoples R China
5.Chinese Acad Sci, State Key Lab Management & Control Complex Syst, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China
6.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100190, Peoples R China
7.Zhejiang Univ, Coll Biomed Engn & Instrument Sci, Hangzhou Inst Innovat Med,Key Lab Biomed Engn, Inst Pharmaceut,Coll Pharmaceut Sci,Minist Educ, Hangzhou 310058, Zhejiang, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Qiyue,Ma, Xibo,Liao, Hongwei,et al. Artificially Engineered Cubic Iron Oxide Nanoparticle as a High-Performance Magnetic Particle Imaging Tracer for Stem Cell Tracking[J]. ACS NANO,2020,14(2):2053-2062.
APA Wang, Qiyue.,Ma, Xibo.,Liao, Hongwei.,Liang, Zeyu.,Li, Fangyuan.,...&Ling, Daishun.(2020).Artificially Engineered Cubic Iron Oxide Nanoparticle as a High-Performance Magnetic Particle Imaging Tracer for Stem Cell Tracking.ACS NANO,14(2),2053-2062.
MLA Wang, Qiyue,et al."Artificially Engineered Cubic Iron Oxide Nanoparticle as a High-Performance Magnetic Particle Imaging Tracer for Stem Cell Tracking".ACS NANO 14.2(2020):2053-2062.

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