Default mode network integrity changes contribute to cognitive deficits in subcortical vascular cognitive impairment, no dementia
文献类型:期刊论文
作者 | Qin, Qi5; Tang, Yi5; Dou, Xuejiao3,4,6; Qu, Yida3,4,6; Xing, Yi5; Yang, Jianwei5; Chu, Tianshu1; Liu, Yong3,4,6,7; Jia, Jianping2,5 |
刊名 | BRAIN IMAGING AND BEHAVIOR |
出版日期 | 2020-03-03 |
页码 | 11 |
ISSN号 | 1931-7557 |
关键词 | Default mode network Diffusion tensor imaging Vascular cognitive impairment no dementia Cognitive function |
DOI | 10.1007/s11682-019-00252-y |
通讯作者 | Tang, Yi(tangyixw@163.com) |
英文摘要 | Vascular cognitive impairment, no dementia (VCIND) refers to cognitive deficits associated with underlying vascular causes that are insufficient to confirm a diagnosis of dementia. The default mode network (DMN) is a large-scale brain network of interacting brain regions involved in attention, working memory and executive function. The role of DMN white matter integrity in cognitive deficits of VCIND patients is unclear. Using diffusion tensor imaging (DTI), this study was carried out to investigate white matter microstructural changes in the DMN in VCIND patients and their contributions to cognitive deficits. Thirty-one patients with subcortical VCIND and twenty-two healthy elderly subjects were recruited. All patients underwent neuropsychological assessments and DTI examination. Voxel-based analyses were performed to extract fractional anisotropy (FA) and mean diffusivity (MD) measures in the DMN. Compared with the healthy elderly subjects, patients diagnosed with subcortical VCIND presented with abnormal white matter integrity in several key hubs of the DMN. The severity of damage in the white matter microstructure in the DMN significantly correlated with cognitive dysfunction. Mediation analyses demonstrated that DTI values could account for attention, executive and language impairments, and partly mediated global cognitive dysfunction in the subcortical VCIND patients. DMN integrity is significantly impaired in subcortical VCIND patients. The disrupted DMN connectivity could explain the attention, language and executive dysfunction, which indicates that the white matter integrity of the DMN may be a neuroimaging marker for VCIND. |
WOS关键词 | ALZHEIMERS-DISEASE ; MRI ; BRAIN ; ABNORMALITIES ; HYPERINTENSITIES ; DYSFUNCTION ; PREVALENCE ; STATE ; CONNECTIVITY ; DISORDERS |
资助项目 | Beijing Natural Science Foundation[JQ19024] ; National Natural Science Foundation of China[81671040] ; National Natural Science Foundation of China[81970996] ; Beijing Municipal Science & Technology Commission[Z191100006619046] ; Beijing Municipal Science & Technology Commission[Z171100000117001] ; Strategic Priority Research Program (B) of the Chinese Academy of Sciences[XDB32020200] |
WOS研究方向 | Neurosciences & Neurology |
语种 | 英语 |
出版者 | SPRINGER |
WOS记录号 | WOS:000518076300005 |
资助机构 | Beijing Natural Science Foundation ; National Natural Science Foundation of China ; Beijing Municipal Science & Technology Commission ; Strategic Priority Research Program (B) of the Chinese Academy of Sciences |
源URL | [http://ir.ia.ac.cn/handle/173211/38416] |
专题 | 自动化研究所_脑网络组研究中心 |
通讯作者 | Tang, Yi |
作者单位 | 1.NYU, Ctr Data Sci, New York, NY USA 2.Minist Educ Peoples Republ China, Neurodegenerat Lab, Beijing Key Lab Geriatr Cognit Disorders, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 4.Chinese Acad Sci, Brainnetome Ctr, Beijing, Peoples R China 5.Capital Med Univ, Xuanwu Hosp, Natl Clin Res Ctr Geriatr Dis, Dept Neurol,Innovat Ctr Neurol Disorders, 45 Changchun St, Beijing 100053, Peoples R China 6.Univ Chinese Acad Sci, Sch Artificial Intelligence, Beijing, Peoples R China 7.Chinese Acad Sci, Inst Automat, CAS Ctr Excellence Brain Sci & Intelligence Techn, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Qin, Qi,Tang, Yi,Dou, Xuejiao,et al. Default mode network integrity changes contribute to cognitive deficits in subcortical vascular cognitive impairment, no dementia[J]. BRAIN IMAGING AND BEHAVIOR,2020:11. |
APA | Qin, Qi.,Tang, Yi.,Dou, Xuejiao.,Qu, Yida.,Xing, Yi.,...&Jia, Jianping.(2020).Default mode network integrity changes contribute to cognitive deficits in subcortical vascular cognitive impairment, no dementia.BRAIN IMAGING AND BEHAVIOR,11. |
MLA | Qin, Qi,et al."Default mode network integrity changes contribute to cognitive deficits in subcortical vascular cognitive impairment, no dementia".BRAIN IMAGING AND BEHAVIOR (2020):11. |
入库方式: OAI收割
来源:自动化研究所
浏览0
下载0
收藏0
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。