Selective intra-arterial brain cooling improves long-term outcomes in a non-human primate model of embolic stroke: Efficacy depending on reperfusion status
文献类型：期刊论文
| 作者 | Wu, Di1,2,3,4; Chen, Jian5 ; Hussain, Mohammed6; Wu, Longfei1,2,3; Shi, Jingfei1,2; Wu, Chuanjie1,2,3; Ma, Yanhui7; Zhang, Mo8; Yang, Qi8; Fu, Yongjuan9
|
| 刊名 | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
 |
| 出版日期 | 2020-03-03 |
| 页码 | 12 |
| ISSN号 | 0271-678X |
| 关键词 | Middle cerebral artery occlusion hypothermia rhesus monkey tissue plasminogen activator reperfusion |
| DOI | 10.1177/0271678X20903697 |
| 通讯作者 | Ji, Xunming(jixm@ccmu.edu.cn) |
| 英文摘要 | Nearly all stroke neuroprotection modalities, including selective intra-arterial cooling (SI-AC), have failed to be translated from bench to bed side. Potentially overlooked reasons may be biological gaps, inadequate attention to reperfusion states and mismatched attention to neurological benefits. To advance stroke translation, we describe a novel thrombus-based stroke model in adult rhesus macaques. Intra-arterial thrombolysis with tissue plasminogen activator leads to three clinically relevant outcomes - complete, partial, and no recanalization based on digital subtraction angiography. We also find reperfusion as a prerequisite for SI-AC-induced benefits, in which models with complete or partial reperfusion exhibit significantly reduced infarct volumes, mitigated neurological deficits, improved upper limb motor dysfunction in both acute and chronic stages; however, no further neuroprotection is observed in those without reperfusion. In summary, we discover reperfusion as a crucial regulator of SI-AC-induced neuroprotection and provide insights of long-term functional benefits in behavior and imaging levels. Our findings could be important not only for the translational prerequisite and potential molecular targets, but also for this thrombus-thrombolysis model in monkeys as a powerful tool for further translational stroke studies. |
| WOS关键词 | ACUTE ISCHEMIC-STROKE ; ENDOVASCULAR THROMBECTOMY ; INTRAVENOUS THROMBOLYSIS ; CEREBRAL-ISCHEMIA ; HYPOTHERMIA ; NEUROPROTECTION ; OCCLUSION ; INFUSION ; UPDATE ; TRIAL |
| 资助项目 | Chang Jiang Scholars Program from the Chinese Ministry of Education[T2014251] ; National Natural Science Foundation of China for Outstanding Youth[81325007] ; National Natural Science Foundation of China[81620108011] ; National Natural Science Foundation of China[81871022] ; National Natural Science Foundation of China[81771260] ; National Key R&D Program of China[2017YFC1308401] ; mission talent project of Beijing Municipal Administration of Hospitals[SML20150802] ; Beijing Municipal Administration of Hospitals' Youth Programme[QML20170802] |
| WOS研究方向 | Endocrinology & Metabolism ; Hematology ; Neurosciences & Neurology |
| 语种 | 英语 |
| 出版者 | SAGE PUBLICATIONS INC |
| WOS记录号 | WOS:000517872900001 |
| 资助机构 | Chang Jiang Scholars Program from the Chinese Ministry of Education ; National Natural Science Foundation of China for Outstanding Youth ; National Natural Science Foundation of China ; National Key R&D Program of China ; mission talent project of Beijing Municipal Administration of Hospitals ; Beijing Municipal Administration of Hospitals' Youth Programme |
| 源URL | [http://ir.ia.ac.cn/handle/173211/38442]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 通讯作者 | Ji, Xunming |
| 作者单位 | 1.Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing, Peoples R China 2.Capital Med Univ, Xuanwu Hosp, China Amer Inst Neurosci, Beijing 100053, Peoples R China 3.Beijing Key Lab Hypoxia Conditioning Translat Med, Beijing, Peoples R China 4.Beijing Inst Brain Disorders, Ctr Stroke, Beijing, Peoples R China 5.Capital Med Univ, Xuanwu Hosp, Dept Neurosurg, Beijing, Peoples R China 6.Wayne State Univ, Sch Med, Dept Neurosurg, Detroit, MI USA 7.Capital Med Univ, Xuanwu Hosp, Dept Anesthesiol, Beijing, Peoples R China 8.Capital Med Univ, Xuanwu Hosp, Dept Radiol, Beijing, Peoples R China 9.Capital Med Univ, Xuanwu Hosp, Dept Pathol, Beijing, Peoples R China 10.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Interdisciplinary Innovat Inst Med & Engn, Sch Biol Sci & Med Engn, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Di,Chen, Jian,Hussain, Mohammed,et al. Selective intra-arterial brain cooling improves long-term outcomes in a non-human primate model of embolic stroke: Efficacy depending on reperfusion status[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,2020:12. |
| APA | Wu, Di.,Chen, Jian.,Hussain, Mohammed.,Wu, Longfei.,Shi, Jingfei.,...&Ji, Xunming.(2020).Selective intra-arterial brain cooling improves long-term outcomes in a non-human primate model of embolic stroke: Efficacy depending on reperfusion status.JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,12. |
| MLA | Wu, Di,et al."Selective intra-arterial brain cooling improves long-term outcomes in a non-human primate model of embolic stroke: Efficacy depending on reperfusion status".JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2020):12. |
入库方式： OAI收割
来源：自动化研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。