Impact of AVM location on language cortex right-hemisphere reorganization: A voxel-based lesion-symptom mapping study
文献类型：期刊论文
| 作者 | Deng, Xiaofeng4; Wei, Xuehu1,2; Zhang, Yan4; Wang, Bo3 ; Zhang, Dong4; Yu, Shaochen4; Jiang, Tianzi1,2; Zhao, Jizong4
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| 刊名 | CLINICAL NEUROLOGY AND NEUROSURGERY
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| 出版日期 | 2020-02-01 |
| 卷号 | 189页码:6 |
| 关键词 | Cerebral arteriovenous malformation Language cortex reorganization Stroke Functional magnetic resonance imaging VLSM |
| ISSN号 | 0303-8467 |
| DOI | 10.1016/j.clineuro.2019.105628 |
| 通讯作者 | Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn) ; Zhao, Jizong(zhaojz205@163.com) |
| 英文摘要 | Objectives: Cerebral arteriovenous malformations (AVMs) are congenital malformations, and right-sided dominance of the language cortex is not a rare phenomenon for patients with AVM involving language area. We tried to use voxel-based lesion-symptom mapping (VLSM) method to depict the location of AVM nidus and to demonstrate the relationship between AVM location and the pattern of language cortex reorganization. Patients and methods: The authors retrospectively reviewed clinical and imaging data of 70 adult patients with unruptured cerebral AVMs who underwent blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) of language task. All patients were right handed, and all lesions were located in the left cerebral hemisphere. Lateralization indexes (LI) of the BOLD signals were calculated for Broca and Wernicke areas separately and were used to reflect the degree of right-sided dominance of the two language areas. VLSM method was applied to study the relationship between AVM location and LI of language task activations. Results: Statistical analysis revealed that the change of LI of Broca area was significantly associated with lesions located in the inferior frontal gyrus, pre- and post-central gyrus, supramarginal gyrus and middle frontal gyrus. The change of LI of Wernicke area was significantly associated with lesions located in the left superior, middle, inferior and transverse temporal gyrus. Conclusion: These findings provide new evidence that the language cortex reorganization patterns in AVM patients have anatomic specificity. |
| WOS关键词 | TRANSCRANIAL MAGNETIC STIMULATION ; BRAIN ARTERIOVENOUS-MALFORMATIONS ; DOMINANCE ; LATERALIZATION ; SPEECH ; GLIOMAS |
| 资助项目 | Chinese National Natural Science Foundation[81701088] ; Beijing talents project[2017000021469G211] ; capital health research and development of special[2016-2-2043] |
| WOS研究方向 | Neurosciences & Neurology ; Surgery |
| 语种 | 英语 |
| WOS记录号 | WOS:000515210000016 |
| 出版者 | ELSEVIER |
| 资助机构 | Chinese National Natural Science Foundation ; Beijing talents project ; capital health research and development of special |
| 源URL | [http://ir.ia.ac.cn/handle/173211/38448]  |
| 专题 | 自动化研究所_脑网络组研究中心 |
| 通讯作者 | Jiang, Tianzi; Zhao, Jizong |
| 作者单位 | 1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu, Peoples R China 2.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China 3.Chinese Acad Sci, Beijing MRI Ctr Brain Res, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China 4.Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Dept Neurosurg, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Deng, Xiaofeng,Wei, Xuehu,Zhang, Yan,et al. Impact of AVM location on language cortex right-hemisphere reorganization: A voxel-based lesion-symptom mapping study[J]. CLINICAL NEUROLOGY AND NEUROSURGERY,2020,189:6. |
| APA | Deng, Xiaofeng.,Wei, Xuehu.,Zhang, Yan.,Wang, Bo.,Zhang, Dong.,...&Zhao, Jizong.(2020).Impact of AVM location on language cortex right-hemisphere reorganization: A voxel-based lesion-symptom mapping study.CLINICAL NEUROLOGY AND NEUROSURGERY,189,6. |
| MLA | Deng, Xiaofeng,et al."Impact of AVM location on language cortex right-hemisphere reorganization: A voxel-based lesion-symptom mapping study".CLINICAL NEUROLOGY AND NEUROSURGERY 189(2020):6. |
入库方式： OAI收割
来源：自动化研究所
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