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Shared and distinct resting functional connectivity in children and adults with attention-deficit/hyperactivity disorder

文献类型：期刊论文

作者Guo, Xiaojie7,8,9; Yao, Dongren1,5,6; Cao, Qingjiu7,8,9; Liu, Lu7,8,9; Zhao, Qihua7,8,9; Li, Hui7,8,9; Huang, Fang7,8,9; Wang, Yanfei7,8,9; Qian, Qiujin7,8,9; Wang, Yufeng7,8,9
刊名TRANSLATIONAL PSYCHIATRY
出版日期2020-02-12
卷号10期号:1页码:12
ISSN号2158-3188
DOI10.1038/s41398-020-0740-y
通讯作者Sui, Jing(jing.sui@nlpr.ia.ac.cn) ; Sun, Li(sunlioh@bjmu.edu.cn)
英文摘要Attention-deficit/hyperactivity disorder (ADHD) often persists into adulthood, with a shift of symptoms including less hyperactivity/impulsivity and more co-morbidity of affective disorders in ADHD(adult). Many studies have questioned the stability in diagnosing of ADHD from childhood to adulthood, and the shared and distinct aberrant functional connectivities (FCs) between ADHD(child) and ADHD(adult) remain unidentified. We aim to explore shared and distinct FC patterns in ADHD(child) and ADHD(adult), and further investigated the cross-cohort predictability using the identified FCs. After investigating the ADHD-discriminative FCs from healthy controls (HCs) in both child (34 ADHD(child), 28 HCs) and adult (112 ADHD(adult),77 HCs) cohorts, we identified both shared and distinct aberrant FC patterns between cohorts and their association with clinical symptoms. Moreover, the cross-cohort predictability using the identified FCs were tested. The ADHD-HC classification accuracies were 84.4% and 81.0% for children and male adults, respectively. The ADHD-discriminative FCs shared in children and adults lie in the intra-network within default mode network (DMN) and the inter-network between DMN and ventral attention network, positively correlated with total scores of ADHD symptoms. Particularly, inter-network FC between somatomotor network and dorsal attention network was uniquely impaired in ADHD(child), positively correlated with hyperactivity index; whereas the aberrant inter-network FC between DMN and limbic network exhibited more adult-specific ADHD dysfunction. And their cross-cohort predictions were 70.4% and 75.6% between each other. This work provided imaging evidence for symptomatic changes and pathophysiological continuity in ADHD from childhood to adulthood, suggesting that FCs may serve as potential biomarkers for ADHD diagnosis.
WOS关键词DEFICIT HYPERACTIVITY DISORDER ; DEFAULT NETWORK ; BRAIN ; ADHD ; METAANALYSIS ; RELIABILITY ; SELECTION ; SYSTEMS ; FMRI
资助项目National Key Technology RD Program[2016YFC1306103] ; National Natural Sciences Foundation of China[81771479] ; National Natural Sciences Foundation of China[81971284] ; National Natural Sciences Foundation of China[61773380] ; National Natural Sciences Foundation of China[81873802] ; Beijing municipal science and technology Program[Z171100001017089] ; Beijing municipal science and technology Program[Z171100000117004] ; Beijing municipal science and technology Program[Z181100001518005] ; Beijing Natural Science Foundation[7172245] ; National Institutes of Health[R01EB020407] ; National Institutes of Health[R01EB006841] ; National Institutes of Health[P20GM103472] ; National Institutes of Health[P30GM122734] ; Sanming Project of Medicine in Shenzhen The ADHD research group from Peking University Sixth hospital[SZSM201612036]
WOS研究方向Psychiatry
语种英语
出版者NATURE PUBLISHING GROUP
WOS记录号WOS:000515817700003
资助机构National Key Technology RD Program ; National Natural Sciences Foundation of China ; Beijing municipal science and technology Program ; Beijing Natural Science Foundation ; National Institutes of Health ; Sanming Project of Medicine in Shenzhen The ADHD research group from Peking University Sixth hospital
源URL[http://ir.ia.ac.cn/handle/173211/38500]  
专题自动化研究所_脑网络组研究中心
通讯作者Sui, Jing; Sun, Li
作者单位1.Chinese Acad Sci, Natl Lab Pattern Recognit, Inst Automat, Beijing 100190, Peoples R China
2.Chinese Acad Sci, CAS Ctr Excellence Brain Sci, Inst Automat, Beijing, Peoples R China
3.Univ Wollongong, Sch Psychol, Brain & Behav Res Inst, Wollongong, NSW, Australia
4.Emory Univ, Georgia State Univ, Georgia Inst Technol, Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA 30303 USA
5.Univ Chinese Acad Sci, Beijing, Peoples R China
6.Chinese Acad Sci, Brainnetome Ctr, Beijing 100190, Peoples R China
7.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China
8.Peking Univ, Natl Clin Res Ctr Mental Disorders, Beijing 100191, Peoples R China
9.Peking Univ, Hosp 6, Inst Mental Hlth, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714		 Guo, Xiaojie,Yao, Dongren,Cao, Qingjiu,et al. Shared and distinct resting functional connectivity in children and adults with attention-deficit/hyperactivity disorder[J]. TRANSLATIONAL PSYCHIATRY,2020,10(1):12.
APA Guo, Xiaojie.,Yao, Dongren.,Cao, Qingjiu.,Liu, Lu.,Zhao, Qihua.,...&Sun, Li.(2020).Shared and distinct resting functional connectivity in children and adults with attention-deficit/hyperactivity disorder.TRANSLATIONAL PSYCHIATRY,10(1),12.
MLA Guo, Xiaojie,et al."Shared and distinct resting functional connectivity in children and adults with attention-deficit/hyperactivity disorder".TRANSLATIONAL PSYCHIATRY 10.1(2020):12.

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来源：自动化研究所

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