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Nitrogen and boron dual-doped graphene quantum dots for near-infrared second window imaging and photothermal therapy

文献类型：期刊论文

作者Wang, Hui1,4; Mu, Qingxin1; Wang, Kui1; Revia, Richard A.1; Yen, Charles1; Gu, Xinyu3; Tian, Bowei2; Liu, Jun1; Zhang, Miqin1
刊名APPLIED MATERIALS TODAY
出版日期2019-03-01
卷号14期号:无页码:108-117
关键词Theranostic nanoparticle NIR II fluorescence imaging Graphene quantum dot Photothermal effect Cancer therapy
ISSN号2352-9407
DOI10.1016/j.apmt.2018.11.011
英文摘要

Fluorescence imaging of biological systems in the second near-infrared window (NIR-II) has recently drawn much attention because of its negligible background noise of autofluorescence and low tissue scattering. Here we present a new NIR-II fluorescent agent, graphene quantum dots dual-doped with both nitrogen and boron (N-B-GQDs). N-B-GQDs have an ultra-small size (similar to 5 nm), are highly stable in serum, and demonstrate a peak fluorescent emission at 1000 nm and high photostability. In addition to the NIR-II imaging capability, N-B-GQDs efficiently absorb and convert NIR light into heat when irradiated by an external NIR source, demonstrating a photothermal therapeutic effect that kills cancer cells in vitro and completely suppresses tumor growth in a glioma xenograft mouse model. N-B-GQDs demonstrate a safe profile, prolonged blood half-life, and rapid excretion in mice, which are the characteristics favorable for in vivo biomedical applications. (C) 2018 Elsevier Ltd. All rights reserved.

WOS关键词CARBON NANOTUBES ; PHOTOLUMINESCENCE PROPERTIES ; FLUORESCENT ; FLUOROPHORES ; EMISSION ; SKIN
资助项目NIH[S10 OD016240] ; NIH[R031CA161953]
WOS研究方向Materials Science
语种英语
WOS记录号WOS:000458430900012
出版者ELSEVIER SCIENCE BV
资助机构NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH ; NIH
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/42160]  
专题合肥物质科学研究院_中科院强磁场科学中心
通讯作者Zhang, Miqin
作者单位1.Univ Washington, Dept Mat Sci & Engn, Seattle, WA 98195 USA
2.Univ Washington, Dept Appl Math, Seattle, WA 98195 USA
3.Univ Washington, Dept Biochem, Seattle, WA 98195 USA
4.Chinese Acad Sci, Hefei Inst Phys Sci, High Magnet Field Lab, Hefei 230031, Anhui, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Hui,Mu, Qingxin,Wang, Kui,et al. Nitrogen and boron dual-doped graphene quantum dots for near-infrared second window imaging and photothermal therapy[J]. APPLIED MATERIALS TODAY,2019,14(无):108-117.
APA Wang, Hui.,Mu, Qingxin.,Wang, Kui.,Revia, Richard A..,Yen, Charles.,...&Zhang, Miqin.(2019).Nitrogen and boron dual-doped graphene quantum dots for near-infrared second window imaging and photothermal therapy.APPLIED MATERIALS TODAY,14(无),108-117.
MLA Wang, Hui,et al."Nitrogen and boron dual-doped graphene quantum dots for near-infrared second window imaging and photothermal therapy".APPLIED MATERIALS TODAY 14.无(2019):108-117.

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来源：合肥物质科学研究院

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