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  4. 技术生物与农业工程研究所
Nanostructure-enhanced water interaction to increase the dual-mode MR contrast performance of gadolinium-doped iron oxide nanoclusters

文献类型：期刊论文

作者Si, Yuanchun1,3; Zhang, Guilong4; Wang, Dan3; Zhang, Cheng5; Yang, Chi1; Bai, Guo1; Qian, Junchao2; Chen, Qiaoer3; Zhang, Zhiyuan1; Wu, Zhengyan4
刊名CHEMICAL ENGINEERING JOURNAL
出版日期2019-03-15
卷号360页码:289-298
关键词Magnetic resonance imaging Water molecules Hydrogen bond Oxygen vacancy Contrast enhancement
ISSN号1385-8947
DOI10.1016/j.cej.2018.11.219
通讯作者Xu, Yunsheng(xuyunsheng1018@163.com) ; Zou, Duohong(zouduohong@126.com)
英文摘要Rational structure design benefits the development of new classes of contrast agents (CAs) with excellent magnetic resonance imaging performance. In this work, hydrogenated silica with a net nanostructure (HSiO2) was fabricated and used to modify gadolinium-doped iron oxide nanoclusters (GdIONCs) to form a core-shell nanoplatform (HSiO2@GdIONC) with enhanced T-1 and T-2 contrast ability. In this nanoplatform, the HSiO2 shell showed a strong binding capacity for water molecules because of the presence of hydrogen bonds, oxygen vacancies, and high specific surface areas, and the strong binding capacity significantly improved the spin-spin (T-2) and spin-lattice (T-1) imaging of the GdIONC core. In addition, the T-1 relaxation rate of the GdIONC core dramatically increased from 30.8 mM(-1) s(-1) to 38.2mM(-1) s(-1) after being coated with the HSiO2 shell, and the r(2) to r(1) ratio decreased from 10.9 to 8.3, which is an appropriate ratio (r(2)/r(1): 5-10) for dual-mode contrast. Cell and animal experiments suggested that HSiO2@GdIONC exhibited a better T-1- and T-2-weighted MR imaging effect than the bare GdIONC core, confirming that this strategy for modifying GdIONCs is a beneficial and promising approach for obtaining highly efficient dual-mode CAs.
WOS关键词FE3O4 NANOPARTICLES ; AGENTS ; T-1 ; THERAPY ; SURFACE ; SIZE
资助项目National Natural Science Foundation of China[21407151] ; National Natural Science Foundation of China[81771531] ; National Natural Science Foundation of China[81571395] ; Youth Innovation Promotion Association of Chinese Academy of Sciences[2015385] ; Science and Technology Major Project of Anhui Province[17030701051] ; Natural Science Foundation of Anhui Province[1808085MB38]
WOS研究方向Engineering
语种英语
WOS记录号WOS:000460964000031
出版者ELSEVIER SCIENCE SA
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Youth Innovation Promotion Association of Chinese Academy of Sciences ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Science and Technology Major Project of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province ; Natural Science Foundation of Anhui Province
源URL[http://ir.hfcas.ac.cn:8080/handle/334002/42424]  
专题合肥物质科学研究院_技术生物与农业工程研究所
通讯作者Xu, Yunsheng; Zou, Duohong
作者单位1.Shanghai Jiao Tong Univ, Peoples Hosp 9, Dept Oral Surg, Natl Clin Res Ctr Stomatol,Sch Med,Shanghai Key L, Shanghai 200001, Peoples R China
2.Chinese Acad Sci, Hefei Inst Phys Sci, Hefei Canc Hosp, Hefei 230031, Peoples R China
3.Anhui Med Univ, Stomatol Hosp & Coll, Dept Dent Implant Ctr, Key Lab Oral Dis Res Anhui Prov, Hefei 230032, Anhui, Peoples R China
4.Chinese Acad Sci, Hefei Inst Phys Sci, Key Lab High Magnet Field & Ion Beam Phys Biol, Hefei 230031, Peoples R China
5.Wenzhou Med Univ, Dept Dermatovenereol, Affiliated Hosp 1, Wenzhou 325000, Peoples R China
推荐引用方式
GB/T 7714		 Si, Yuanchun,Zhang, Guilong,Wang, Dan,et al. Nanostructure-enhanced water interaction to increase the dual-mode MR contrast performance of gadolinium-doped iron oxide nanoclusters[J]. CHEMICAL ENGINEERING JOURNAL,2019,360:289-298.
APA Si, Yuanchun.,Zhang, Guilong.,Wang, Dan.,Zhang, Cheng.,Yang, Chi.,...&Zou, Duohong.(2019).Nanostructure-enhanced water interaction to increase the dual-mode MR contrast performance of gadolinium-doped iron oxide nanoclusters.CHEMICAL ENGINEERING JOURNAL,360,289-298.
MLA Si, Yuanchun,et al."Nanostructure-enhanced water interaction to increase the dual-mode MR contrast performance of gadolinium-doped iron oxide nanoclusters".CHEMICAL ENGINEERING JOURNAL 360(2019):289-298.

入库方式： OAI收割

来源：合肥物质科学研究院

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