Antimicrobial Sesquiterpenoid Derivatives and Monoterpenoids from the Deep-Sea Sediment-Derived Fungus Aspergillus versicolor SD-330
文献类型：期刊论文
| 作者 | Li, XD; Li, XM; Yin, XL ; Li, X; Wang, BG
|
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2019-10 |
| 卷号 | 17期号:10页码:563 |
| 关键词 | deep-sea sediment-derived fungus Aspergillus versicolor bisabolane-type sesquiterpenoids monoterpenoids antimicrobial activity |
| DOI | 10.3390/md17100563 |
| 产权排序 | [Li, Xiao-Dong ; Li, Xiao-Ming ; Li, Xin ; Wang, Bin-Gui] Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China ; [Li, Xiao-Dong ; Yin, Xiu-Li] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Chunhui Rd 17, Yantai 264003, Peoples R China ; [Li, Xiao-Ming ; Li, Xin ; Wang, Bin-Gui] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Shandong, Peoples R China ; [Li, Xiao-Ming ; Li, Xin ; Wang, Bin-Gui] Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China |
| 文献子类 | Article |
| 英文摘要 | Two new antimicrobial bisabolane-type sesquiterpenoid derivatives, ent-aspergoterpenin C (compound 1) and 7-O-methylhydroxysydonic acid (2), and two new butyrolactone-type monoterpenoids, pestalotiolactones C (3) and D (4), along with a known monoterpenoid pestalotiolactone A (5) and four known bisabolane sesquiterpenoids (6-9), were isolated and identified from the deep-sea sediment-derived fungus Aspergillus versicolor SD-330. The structures of these compounds were elucidated on the basis of spectroscopic analysis, and the absolute configurations of the new compounds 1-4 were determined by the combination of NOESY and TDDFT-ECD calculations and X-ray crystallographic analysis. Additionally, we first determined and reported the absolute configuration of the known monoterpenoid pestalotiolactone A (5) through the X-ray crystallographic experiment. All of these isolated compounds were evaluated for antimicrobial activities against human and aquatic pathogenic bacteria. Compounds 1, 2, 6 and 9 exhibited selective inhibitory activities against zoonotic pathogenic bacteria such as Escherichia coli, Edwardsiella tarda, Vibrio anguillarum and V. harveyi, with MIC values ranging from 1.0 to 8.0 mu g/mL. |
| WOS关键词 | BISABOLANE SESQUITERPENES ; SECONDARY METABOLITES ; ENDOPHYTIC FUNGUS ; SYDONIC ACID ; A-D ; ALKALOIDS |
| WOS研究方向 | Chemistry, Medicinal |
| 语种 | 英语 |
| WOS记录号 | WOS:000498064500023 |
| 资助机构 | Strategic Priority Research Program of the Chinese Academy of SciencesChinese Academy of Sciences [XDA22050401] ; Aoshan Scientific and Technological Innovation Project of Qingdao National Laboratory for Marine Science and Technology [2016ASKJ14] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31700043] ; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2016LH00033, 2017M612358, 2017M612360] ; Research Vessel KEXUE of the National Major Science and Technology Infrastructure from the Chinese Academy of Sciences [KEXUE2018G28] ; Taishan Scholar Project from Shandong Province ; Shandong Provincial Natural Science FoundationNatural Science Foundation of Shandong Province [ZR2017BB073] |
| 源URL | [http://ir.yic.ac.cn/handle/133337/24841]  |
| 专题 | 烟台海岸带研究所_支撑部门 |
| 作者单位 | 1.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Wenhai Rd 1, Qingdao 266237, Shandong, Peoples R China; 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Chunhui Rd 17, Yantai 264003, Peoples R China; 3.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China; 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, XD,Li, XM,Yin, XL,et al. Antimicrobial Sesquiterpenoid Derivatives and Monoterpenoids from the Deep-Sea Sediment-Derived Fungus Aspergillus versicolor SD-330[J]. MARINE DRUGS,2019,17(10):563. |
| APA | Li, XD,Li, XM,Yin, XL,Li, X,&Wang, BG.(2019).Antimicrobial Sesquiterpenoid Derivatives and Monoterpenoids from the Deep-Sea Sediment-Derived Fungus Aspergillus versicolor SD-330.MARINE DRUGS,17(10),563. |
| MLA | Li, XD,et al."Antimicrobial Sesquiterpenoid Derivatives and Monoterpenoids from the Deep-Sea Sediment-Derived Fungus Aspergillus versicolor SD-330".MARINE DRUGS 17.10(2019):563. |
入库方式： OAI收割
来源：烟台海岸带研究所
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