Combinatorial immune and stress response, cytoskeleton and signal transduction effects of graphene and triphenyl phosphate (TPP) in mussel Mytilus galloprovincialis
文献类型：期刊论文
| 作者 | Meng, XJ; Li, F ; Wang, XQ; Liu, JL; Ji, CL; Wu, HF
|
| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2019-10-15 |
| 卷号 | 378页码:UNSP 120778 |
| 关键词 | Joint effects Graphene Triphenyl phosphate (TPP) Toxicity Mussel |
| ISSN号 | 0304-3894 |
| DOI | 10.1016/j.jhazmat.2019.120778 |
| 产权排序 | [Meng, Xiangjing ; Li, Fei ; Wang, Xiaoqing ; Liu, Jialin ; Ji, Chenglong ; Wu, Huifeng] Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc,YICCAS, Yantai 264003, Peoples R China ; [Ji, Chenglong ; Wu, Huifeng] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Shandong, Peoples R China ; [Meng, Xiangjing ; Wang, Xiaoqing] Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 文献子类 | Article |
| 英文摘要 | Owing to its unique surface properties, graphene can absorb environmental pollutants, thereby affecting their environmental behavior. Triphenyl phosphate (TPP) is a highly produced flame retardant. However, the toxicities of graphene and its combinations with contaminants remain largely unexplored. In this work, we investigated the toxicological effects of graphene and TPP to mussel Mytilus galloprovincialis. Results indicated that graphene could damage the digestive gland tissues, but no significant changes were found in the graphene + TPP co-exposure group. There was a significant decrease in the content of GSH and the activities of GST and CAT in the co-exposure group compared to that in graphene-exposed group. It seemed that the adsorption of TPP on graphene could inhibit the surface activity of graphene and thus reduced its tissue damage and oxidative stress in mussels. Expression levels of stress response (MyD88a), cytoskeleton (MHC1, PMyo and TMyo) and reproductive (CP450 and HSD) genes were up-regulated in the graphene-exposed group, but significantly down-regulated after combined exposure of graphene and TPP. Furthermore, PPI analysis proved that the interactions of HSP90AA1 with UNC45B and FKBP4/5/6/L contributed to the toxicity caused by the combined exposure. Because of the potential toxicity of graphene and TPP, government administrators should consider its risks prior to the widespread environmental exposure. |
| WOS关键词 | ORGANOPHOSPHATE FLAME RETARDANTS ; MESSENGER-RNA EXPRESSION ; DEVELOPMENTAL TOXICITY ; OXIDATIVE STRESS ; OXIDE ; MECHANISMS ; NETWORK ; PLASTICIZERS ; CYTOTOXICITY ; ECOTOXICITY |
| WOS研究方向 | Engineering, Environmental ; Environmental Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000489188300067 |
| 资助机构 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China [41530642, 21677173] ; Youth Innovation Promotion Association CAS [2017255, 2015169] |
| 源URL | [http://ir.yic.ac.cn/handle/133337/24833]  |
| 专题 | 烟台海岸带研究所_近岸生态与环境实验室 烟台海岸带研究所_支撑部门 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res YIC, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Shandong Key Lab Coastal Environm Proc,YICCAS, Yantai 264003, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Shandong, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Meng, XJ,Li, F,Wang, XQ,et al. Combinatorial immune and stress response, cytoskeleton and signal transduction effects of graphene and triphenyl phosphate (TPP) in mussel Mytilus galloprovincialis[J]. JOURNAL OF HAZARDOUS MATERIALS,2019,378:UNSP 120778. |
| APA | Meng, XJ,Li, F,Wang, XQ,Liu, JL,Ji, CL,&Wu, HF.(2019).Combinatorial immune and stress response, cytoskeleton and signal transduction effects of graphene and triphenyl phosphate (TPP) in mussel Mytilus galloprovincialis.JOURNAL OF HAZARDOUS MATERIALS,378,UNSP 120778. |
| MLA | Meng, XJ,et al."Combinatorial immune and stress response, cytoskeleton and signal transduction effects of graphene and triphenyl phosphate (TPP) in mussel Mytilus galloprovincialis".JOURNAL OF HAZARDOUS MATERIALS 378(2019):UNSP 120778. |
入库方式： OAI收割
来源：烟台海岸带研究所
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