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Meta-analytic evidence for the anti-aging effect of hormesis on Caenorhabditis elegans

文献类型：期刊论文

作者Sun, Tao; Wu, Huifeng; Cong, Ming; Zhan, Junfei; Li, Fei
刊名AGING-US
出版日期2020-02-15
卷号12期号:3页码:2723-2746
关键词LIFE-SPAN OXIDATIVE STRESS TRADE-OFFS DAF-16 ROS ANTIOXIDANT HEALTHSPAN LONGEVITY GENETICS EXERCISE
DOI10.18632/aging.102773
产权排序[Sun, Tao ; Wu, Huifeng ; Cong, Ming ; Zhan, Junfei ; Li, Fei] Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC, Yantai 264003, Peoples R China ; [Sun, Tao ; Wu, Huifeng ; Cong, Ming ; Zhan, Junfei ; Li, Fei] YICCAS, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China ; [Wu, Huifeng] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China ; [Sun, Tao ; Zhan, Junfei] Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Wu, Huifeng ; Cong, Ming ; Li, Fei] Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
文献子类Article
英文摘要Mild stress-induced hormesis, as a promising strategy to improve longevity and healthy aging, meets both praise and criticism. To comprehensively assess the applicability of hormesis in aging intervention, this meta-analysis was conducted focusing on the effect of hormesis on Caenorhabditis elegans. Twenty-six papers involving 198 effect size estimates met the inclusion criteria. Meta-analytic results indicated that hormesis could significantly extend the mean lifespan of C. elegans by 16.7% and 25.1% under normal and stress culture conditions (p < 0.05), respectively. The healthspan assays showed that hormesis remarkably enhanced the bending frequency and pumping rate of worms by 28.9% and 7.0% (p < 0.05), respectively, while effectively reduced the lipofuscin level by 15.9% (p < 0.05). The obviously increased expression of dauer formation protein-16 (1.66-fold) and its transcriptional targets, including superoxide dismutase-3 (2.46-fold), catalase-1 (2.32-fold) and small heat shock protein-16.2 (2.88-fold) (p < 0.05), was one of the molecular mechanisms underlying these positive effects of hormesis. This meta-analysis provided strong evidence for the anti-aging role of hormesis, highlighting its lifespan-prolonging, healthspan-enhancing and resistance-increasing effects on C. elegans. Given that dauer formation protein-16 was highly conservative, hormesis offered the theoretical possibility of delaying intrinsic aging through exogenous intervention among humans.
WOS关键词LIFE-SPAN ; OXIDATIVE STRESS ; TRADE-OFFS ; DAF-16 ; ROS ; ANTIOXIDANT ; HEALTHSPAN ; LONGEVITY ; GENETICS ; EXERCISE
语种英语
WOS记录号WOS:000514798700044
资助机构Young Taishan Scholars Program of Shandong Province [tsqn201812115] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [21677173] ; Youth Innovation Promotion Association CAS [2017255]
源URL[http://ir.yic.ac.cn/handle/133337/25087]  
专题烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
烟台海岸带研究所_近岸生态与环境实验室
作者单位1.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266237, Peoples R China;
2.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China;
4.Chinese Acad Sci, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai Inst Coastal Zone Res YIC, Yantai 264003, Peoples R China;
5.YICCAS, Shandong Key Lab Coastal Environm Proc, Yantai 264003, Peoples R China;
推荐引用方式
GB/T 7714		 Sun, Tao,Wu, Huifeng,Cong, Ming,et al. Meta-analytic evidence for the anti-aging effect of hormesis on Caenorhabditis elegans[J]. AGING-US,2020,12(3):2723-2746.
APA Sun, Tao,Wu, Huifeng,Cong, Ming,Zhan, Junfei,&Li, Fei.(2020).Meta-analytic evidence for the anti-aging effect of hormesis on Caenorhabditis elegans.AGING-US,12(3),2723-2746.
MLA Sun, Tao,et al."Meta-analytic evidence for the anti-aging effect of hormesis on Caenorhabditis elegans".AGING-US 12.3(2020):2723-2746.

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来源：烟台海岸带研究所

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