Rotational paper-based electrochemiluminescence immunodevices for sensitive and multiplexed detection of cancer biomarkers
文献类型：期刊论文
| 作者 | Sun, Xiange; Li, Bowei ; Tian, Chunyuan; Yu, Fabiao; Zhou, Na; Zhan, Yinghua; Chen, Lingxin
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| 刊名 | ANALYTICA CHIMICA ACTA
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| 出版日期 | 2018-05-12 |
| 卷号 | 1007页码:33-39 |
| 关键词 | Microfluidic paper-based device Electrochemiluminescence immunoassay Valve Cancer biomarker Point-of-care |
| ISSN号 | 0003-2670 |
| DOI | 10.1016/j.aca.2017.12.005 |
| 产权排序 | [Sun, Xiange ; Li, Bowei ; Yu, Fabiao ; Zhou, Na ; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China ; [Tian, Chunyuan] Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China ; [Sun, Xiange] Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Zhan, Yinghua] Yantai Xinhua Hlth Outpatient Dept, Yantai 264003, Peoples R China |
| 文献子类 | Article |
| 英文摘要 | This paper describes a novel rotational paper-based analytical device (RPAD) to implement multi-step electrochemiluminescence (ECL) immunoassays. The integrated paper-based rotational valves can be easily controlled by rotating paper discs manually and this advantage makes it user-friendly to untrained users to carry out the multi-step assays. In addition, the rotational valves are reusable and the response time can be shortened to several seconds, which promotes the rotational paper-based device to have great advantages in multi-step operations. Under the control of rotational valves, multi-step ECL immunoassays were conducted on the rotational device for the multiplexed detection of carcinoembryonic antigen (CEA) and prostate specific antigen (PSA). The rotational device exhibited excellent analytical performance for CEA and PSA, and they could be detected in the linear ranges of 0.1-100 ngmL(-1) and 0.1-50 ng mL(-1) with detection limits down to 0.07 ng mL(-1) and 0.03 ng mL(-1), respectively, which were within the ranges of clinical concentrations. We hope this technique will open a new avenue for the fabrication of paper-based valves and provide potential application in clinical diagnostics. (C) 2017 Elsevier B.V. All rights reserved. |
| WOS关键词 | ANALYTICAL DEVICES ; MICROFLUIDIC CHIP ; FLUORESCENCE DETECTION ; IMMUNOASSAY ; FLOW ; INTEGRATION ; DIAGNOSTICS ; STRATEGY ; PROGRESS ; ARRAYS |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000423843500005 |
| 资助机构 | National Natural Science Foundation of China [41776110, 21205131, 21775162] ; Science and Technology Development Plan of Yantai [2015ZH087] ; National Key Research and Development Program of China [2016YFC1400702] ; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry |
| 源URL | [http://ir.yic.ac.cn/handle/133337/24370]  |
| 专题 | 烟台海岸带研究所_山东省海岸带环境工程技术研究中心 烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; 2.Yantai Univ, Coll Chem & Chem Engn, Yantai 264005, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 4.Yantai Xinhua Hlth Outpatient Dept, Yantai 264003, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, Xiange,Li, Bowei,Tian, Chunyuan,et al. Rotational paper-based electrochemiluminescence immunodevices for sensitive and multiplexed detection of cancer biomarkers[J]. ANALYTICA CHIMICA ACTA,2018,1007:33-39. |
| APA | Sun, Xiange.,Li, Bowei.,Tian, Chunyuan.,Yu, Fabiao.,Zhou, Na.,...&Chen, Lingxin.(2018).Rotational paper-based electrochemiluminescence immunodevices for sensitive and multiplexed detection of cancer biomarkers.ANALYTICA CHIMICA ACTA,1007,33-39. |
| MLA | Sun, Xiange,et al."Rotational paper-based electrochemiluminescence immunodevices for sensitive and multiplexed detection of cancer biomarkers".ANALYTICA CHIMICA ACTA 1007(2018):33-39. |
入库方式： OAI收割
来源：烟台海岸带研究所
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