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Evaluation of Glutathione S-Transferase Inhibition Effects on Idiopathic Pulmonary Fibrosis Therapy with a Near-Infrared Fluorescent Probe in Cell and Mice Models

文献类型：期刊论文

作者He, N; Bai, S; Huang, Y; Xing, YL; Chen, LX; Yu, FB; Lv, CJ
刊名ANALYTICAL CHEMISTRY
出版日期2019-04-16
卷号91期号:8页码:5424-5432
关键词DESIGN STRATEGIES OXIDATIVE STRESS MOLECULAR DESIGN SUBSTRATE AGGREGATION INJURY SITES A1-1
ISSN号0003-2700
DOI10.1021/acs.analchem.9b00713
产权排序[He, Na ; Bai, Song ; Lv, Changjun] Binzhou Med Univ Hosp, Dept Resp Med, Binzhou 256603, Peoples R China ; [Huang, Yan ; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China ; [Xing, Yanlong ; Yu, Fabiao] Hainan Med Univ, Coll Emergency & Trauma, Key Lab Hainan Trauma & Disaster Rescue, Inst Funct Mat & Mol Imaging,Coll Clin med, Haikou 571199, Hainan, Peoples R China ; [He, Na ; Bai, Song ; Lv, Changjun] Binzhou Med Univ, Inst Mol Med, Med Res Ctr, Yantai 264003, Peoples R China
文献子类Article
英文摘要Idiopathic pulmonary fibrosis (IPF) is a lung-limited and progressive fibrotic disease. The early diagnosis and therapies of IPF are still full of clinical challenges. Glutathione S-transferase (GSTs) plays significant roles in promoting the formation of pulmonary fibrosis. Herein, we report a fluorescent probe (Cy-GST) for the detection of GSTs concentration fluctuations in cells and in mice models. The probe can selectively and sensitively respond to GSTs with an "off-on" type fluorescence switch. Our results demonstrated that the level of intracellular GSTs increase in the pulmonary fibrosis cells and mice models. And the IPF patients hold high levels of GSTs concentrations. Thus, GSTs are likely to play important roles in pulmonary fibrosis. The inhibitor of GSTs TLK117 can reduce the severity of pulmonary fibrosis. The synergistic treatment of TLK117 and pirfenidone have better therapeutic effects than only using pirfenidone in pulmonary fibrosis mice models. The level of GSTs in IPF may be a new potential marker for IPF diagnosis. And the inhibition of GSTs may be a new therapeutic strategy for IPF treatment.
WOS关键词DESIGN STRATEGIES ; OXIDATIVE STRESS ; MOLECULAR DESIGN ; SUBSTRATE ; AGGREGATION ; INJURY ; SITES ; A1-1
WOS研究方向Chemistry, Analytical
语种英语
WOS记录号WOS:000465189600066
资助机构National Nature Science Foundation of ChinaNational Natural Science Foundation of China [21775162, 21864011, 81670064, 81870001] ; Talent Program of Hainan Medical University [XRC180006, XRC180007] ; Medical Science and Technology Development Project of Shandong Province [2017WS800]
源URL[http://ir.yic.ac.cn/handle/133337/24957]  
专题烟台海岸带研究所_山东省海岸带环境工程技术研究中心
烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China;
2.Binzhou Med Univ Hosp, Dept Resp Med, Binzhou 256603, Peoples R China;
3.Binzhou Med Univ, Inst Mol Med, Med Res Ctr, Yantai 264003, Peoples R China
4.Hainan Med Univ, Coll Emergency & Trauma, Key Lab Hainan Trauma & Disaster Rescue, Inst Funct Mat & Mol Imaging,Coll Clin med, Haikou 571199, Hainan, Peoples R China;
推荐引用方式
GB/T 7714		 He, N,Bai, S,Huang, Y,et al. Evaluation of Glutathione S-Transferase Inhibition Effects on Idiopathic Pulmonary Fibrosis Therapy with a Near-Infrared Fluorescent Probe in Cell and Mice Models[J]. ANALYTICAL CHEMISTRY,2019,91(8):5424-5432.
APA He, N.,Bai, S.,Huang, Y.,Xing, YL.,Chen, LX.,...&Lv, CJ.(2019).Evaluation of Glutathione S-Transferase Inhibition Effects on Idiopathic Pulmonary Fibrosis Therapy with a Near-Infrared Fluorescent Probe in Cell and Mice Models.ANALYTICAL CHEMISTRY,91(8),5424-5432.
MLA He, N,et al."Evaluation of Glutathione S-Transferase Inhibition Effects on Idiopathic Pulmonary Fibrosis Therapy with a Near-Infrared Fluorescent Probe in Cell and Mice Models".ANALYTICAL CHEMISTRY 91.8(2019):5424-5432.

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来源：烟台海岸带研究所

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