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Molecular cloning and characterization of FADD from the manila clam Ruditapes philippinarum

文献类型：期刊论文

作者Hu, GG; Han, YJ; Yang, DL; Cao, RW; Wang, Q; Liu, H; Dong, ZJ; Zhang, XL; Zhang, QQ; Zhao, JM
刊名FISH & SHELLFISH IMMUNOLOGY
出版日期2019-05
卷号88页码:556-566
关键词FADD Ruditapes philippinarum NF-kappa B Apoptosis
ISSN号1050-4648
DOI10.1016/j.fsi.2019.03.033
产权排序[Hu, Gege ; Han, Yijing ; Yang, Dinglong ; Cao, Ruiwen ; Wang, Qing ; Liu, Hui ; Dong, Zhijun ; Zhang, Xiaoli ; Zhang, Qianqian ; Zhao, Jianmin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Muping Coastal Environm Res Stn, Yantai 264003, Peoples R China ; [Yang, Dinglong ; Wang, Qing ; Liu, Hui ; Dong, Zhijun ; Zhang, Xiaoli ; Zhang, Qianqian ; Zhao, Jianmin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai 264003, Peoples R China ; [Zhao, Jianmin] Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Shandong, Peoples R China ; [Hu, Gege ; Han, Yijing ; Cao, Ruiwen] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
文献子类Article
英文摘要Fas-associated protein with death domain (FADD) is an essential element in cell death, and also implicates in cell cycle progression, inflammation and innate immunity. In the study, an FADD (designated as RpFADD) was identified and characterized from manila clam, Ruditapes philippinarum. Multiple alignments and phylogenetic analysis strongly suggested that RpFADD was a new member of the FADD family. The RpFADD transcripts were constitutively expressed in a wide range of tissues, and dominantly expressed in hemocytes. After challenged with Vibrio anguillarum or Micrococcus luteus, the expression level of RpFADD transcripts was significantly induced and reached the maximum level at 72 h and 48 h, respectively. Knockdown of RpFADD down-regulated the transcript levels of Rp1KK, RpTAK1 and RpNF-kappa B with the exception of RpI kappa B. Moreover, RpFADD primarily localized in the cell cytoplasm, and its over-expression promoted the apoptosis of HeLa cells. These results revealed that RpFADD perhaps regulated the NF-kappa B signaling pathways positively, which provided a better understanding of RpFADD in innate immunity.
WOS关键词NF-KAPPA-B ; DEATH DOMAIN ; EXPRESSION ; PROTEIN ; FAS ; ASSOCIATION ; ACTIVATION ; FLICE
WOS研究方向Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
语种英语
WOS记录号WOS:000465060500065
资助机构Strategic Priority Research Program of the Chinese Academy of SciencesChinese Academy of Sciences [XDA23050303] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [41806196] ; Youth Innovation Promotion Association CAS [2016196]
源URL[http://ir.yic.ac.cn/handle/133337/24949]  
专题海岸带生物资源高效利用研究与发展中心
烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
中国科学院牟平海岸带环境综合试验站
作者单位1.Chinese Acad Sci, Ctr Ocean Megasci, Qingdao 266071, Shandong, Peoples R China;
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Res & Dev Ctr Efficient Utilizat Coastal Bioresou, Yantai 264003, Peoples R China;
4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Muping Coastal Environm Res Stn, Yantai 264003, Peoples R China;
推荐引用方式
GB/T 7714		 Hu, GG,Han, YJ,Yang, DL,et al. Molecular cloning and characterization of FADD from the manila clam Ruditapes philippinarum[J]. FISH & SHELLFISH IMMUNOLOGY,2019,88:556-566.
APA Hu, GG.,Han, YJ.,Yang, DL.,Cao, RW.,Wang, Q.,...&Zhao, JM.(2019).Molecular cloning and characterization of FADD from the manila clam Ruditapes philippinarum.FISH & SHELLFISH IMMUNOLOGY,88,556-566.
MLA Hu, GG,et al."Molecular cloning and characterization of FADD from the manila clam Ruditapes philippinarum".FISH & SHELLFISH IMMUNOLOGY 88(2019):556-566.

入库方式： OAI收割

来源：烟台海岸带研究所

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