Effect of lactulose intervention on gut microbiota and short chain fatty acid composition of C57BL/6J mice
文献类型：期刊论文
| 作者 | Zhai, Shixiang; Zhu, Limeng; Qin, Song ; Li, Lili
|
| 刊名 | MICROBIOLOGYOPEN
 |
| 出版日期 | 2018-12 |
| 卷号 | 7期号:6页码:e612 |
| 关键词 | 16S rRNA high-throughput sequencing gut microbiota prebiotic probiotics short chain fatty acids |
| ISSN号 | 2045-8827 |
| DOI | 10.1002/mbo3.612 |
| 产权排序 | [Zhai, Shixiang ; Zhu, Limeng ; Qin, Song ; Li, Lili] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Shandong, Peoples R China ; [Zhai, Shixiang ; Zhu, Limeng] Univ Chinese Acad Sci, Beijing, Peoples R China ; [Zhu, Limeng] Chinese Acad Sci, Inst Proc Engn, Beijing, Peoples R China |
| 文献子类 | Article |
| 英文摘要 | Gut microbiota have strong connections with health. Lactulose has been shown to regulate gut microbiota and benefit host health. In this study, the effect of short-term (3 week) intervention of lactulose on gut microbiota was investigated. Gut microbiota were detected from mouse feces by 16S rRNA high-throughput sequencing, and short chain fatty acids (SCFAs) were detected by gas chromatography-mass spectrometry (GC-MS). Lactulose intervention enhanced the alpha-diversity of the gut microbiota; increased the abundance of hydrogen-producing bacteria Prevotellaceae and Rikenellaceae, probiotics Bifidobacteriaceae and Lactobacillaceae, and mucin-degrading bacteria Akkermansia and Helicobacter; decreased the abundance of harmful bacteria Desulfovibrionaceae and branched-chain SCFAs (BCFAs). These results suggest that lactulose intervention effectively increased the diversity and improved the structure of the intestinal microbiota, which may be beneficial for host health. |
| WOS关键词 | RELATIVE ORGAN WEIGHT ; GROWTH-PERFORMANCE ; FECAL MICROBIOTA ; DIET ; SUPPLEMENTATION ; FERMENTATION ; METABOLISM ; HEALTH ; LACTOBACILLUS ; ALCOHOL |
| WOS研究方向 | Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000453616500014 |
| 资助机构 | National Key Research and Development plan [2017YFC0506200] ; National Natural Science Foundation of China [21306221] ; Science and Technology Major Project of Shandong Province [2015ZDJS03002] |
| 源URL | [http://ir.yic.ac.cn/handle/133337/24594]  |
| 专题 | 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Shandong, Peoples R China; 2.Univ Chinese Acad Sci, Beijing, Peoples R China; 3.Chinese Acad Sci, Inst Proc Engn, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhai, Shixiang,Zhu, Limeng,Qin, Song,et al. Effect of lactulose intervention on gut microbiota and short chain fatty acid composition of C57BL/6J mice[J]. MICROBIOLOGYOPEN,2018,7(6):e612. |
| APA | Zhai, Shixiang,Zhu, Limeng,Qin, Song,&Li, Lili.(2018).Effect of lactulose intervention on gut microbiota and short chain fatty acid composition of C57BL/6J mice.MICROBIOLOGYOPEN,7(6),e612. |
| MLA | Zhai, Shixiang,et al."Effect of lactulose intervention on gut microbiota and short chain fatty acid composition of C57BL/6J mice".MICROBIOLOGYOPEN 7.6(2018):e612. |
入库方式： OAI收割
来源：烟台海岸带研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。