Single-nucleotide polymorphisms of APE1 associated with risk and prognosis of vitiligo in a Han Chinese population
文献类型：期刊论文
| 作者 | Chen, XJ; Chang, LL; Wang, Q; Han, CY; Li, WJ; Tian, FJ; Liu, LQ; Xia, XJ |
| 刊名 | ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE
 |
| 出版日期 | 2019-09 |
| 卷号 | 28期号:9页码:1249-1255 |
| 关键词 | vitiligo APE1 141T > G Asp148Glu risk of vitiligo |
| ISSN号 | 1899-5276 |
| DOI | 10.17219/acem/68364 |
| 产权排序 | [Chen, Xian-Jin ; Wang, Qi ; Han, Chun-Yu ; Xia, Xn-Juan] Qingdao Univ, Med Coll, Dept Dermatol, Affiliated Yantai Yuhuangding Hosp, Yantai, Peoples R China ; [Chang, Li-Li] Qingdao Univ, Med Coll, Dept Intens Care Unit, Affiliated Yantai Yuhuangding Hosp, Yantai, Peoples R China ; [Li, Wen-Jun] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Beijing, Peoples R China ; [Tian, Fu-Jun ; Liu, Li-Qian] Linyi Peoples Hosp, Dept Dermatol, Linyi, Shandong, Peoples R China |
| 文献子类 | Article |
| 英文摘要 | Background. The single-nucleotide polymorphisms (SNPs) of apurinic/apyrimidinicendonuclease 1 (APE1), which has been implicated in cancers and the DNA base excision repair (BER) process, have not been thoroughly investigated in association with the risks of oxidative stress-related vitiligo. Objectives. The aim of this study is to investigate associations between APE1 single-nucleotide polymorphisms 141T > G and 1349T > G and risk and prognosis of vitiligo. Material and methods. From June 2013 to June 2015, a total of 460 vitiligo patients were randomly recruited as a case group; 200 of these patients received narrow bound ultraviolet B (NB-UVB) treatment. Meanwhile, 460 healthy controls were included as a control group. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was performed to explore the distribution frequencies of genotypes. Results. Significant differences were detected between the case group and the control group in the frequencies of the 141T > G and 1349T > G genotypes. At 141T > G, compared with patients carrying the TG + GG genotype, male patients carrying the TT genotype aged more than 20 years with active non-segmental vitiligo, without a family history of vitiligo or other autoimmune diseases, exhibited an increased risk of vitiligo. Binary logistic regression analysis demonstrated that the TT genotype at 141T > G and the non-TT genotype at 1349T > G were independent risk factors for vitiligo development. At 1349T > G, compared with patients carrying the TT genotype, male patients carrying the TG + GG genotype aged more than 20 years with active non-segmental vitiligo, without a family history of vitiligo or other autoimmune diseases, exhibited an increased risk of vitiligo. Moreover, patients carrying 141TG + GG or 1349 TT genotypes had better photochromic effects, lower cumulative radiation doses, shorter treatment times, and earlier first photochromic times. |
| WOS关键词 | DNA-REPAIR ; GENERALIZED VITILIGO ; GENETIC-VARIANTS ; EXCISION ; RECURRENCE ; DISEASE |
| WOS研究方向 | Medicine, Research & Experimental |
| 语种 | 英语 |
| WOS记录号 | WOS:000488601100014 |
| 源URL | [http://ir.yic.ac.cn/handle/133337/24864]  |
| 专题 | 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 作者单位 | 1.Qingdao Univ, Med Coll, Dept Intens Care Unit, Affiliated Yantai Yuhuangding Hosp, Yantai, Peoples R China; 2.Linyi Peoples Hosp, Dept Dermatol, Linyi, Shandong, Peoples R China 3.Qingdao Univ, Med Coll, Dept Dermatol, Affiliated Yantai Yuhuangding Hosp, Yantai, Peoples R China; 4.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Beijing, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Chen, XJ,Chang, LL,Wang, Q,et al. Single-nucleotide polymorphisms of APE1 associated with risk and prognosis of vitiligo in a Han Chinese population[J]. ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE,2019,28(9):1249-1255. |
| APA | Chen, XJ.,Chang, LL.,Wang, Q.,Han, CY.,Li, WJ.,...&Xia, XJ.(2019).Single-nucleotide polymorphisms of APE1 associated with risk and prognosis of vitiligo in a Han Chinese population.ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE,28(9),1249-1255. |
| MLA | Chen, XJ,et al."Single-nucleotide polymorphisms of APE1 associated with risk and prognosis of vitiligo in a Han Chinese population".ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE 28.9(2019):1249-1255. |
入库方式： OAI收割
来源：烟台海岸带研究所
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