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  4. 海岸带生物学与生物资源利用重点实验室
  5. 海岸带生物学与生物资源利用所重点实验室
Effects of phycocyanin in modulating the intestinal microbiota of mice

文献类型：期刊论文

作者Xie, YY; Li, WJ; Zhu, LM; Zhai, SX; Qin, S; Du, ZN
刊名MICROBIOLOGYOPEN
出版日期2019-09
卷号8期号:9页码:e825
关键词16S rRNA high-throughput sequencing intestinal barrier intestinal microbiota phycocyanin
ISSN号2045-8827
DOI10.1002/mbo3.825
产权排序[Xie, Yuanyuan ; Du, Zhenning] Yantai Univ, Yantai, Peoples R China ; [Xie, Yuanyuan ; Li, Wenjun ; Zhu, Limeng ; Zhai, Shixiang ; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China ; [Zhu, Limeng] Chinese Acad Sci, Inst Proc Engn, Beijing, Peoples R China
文献子类Article
英文摘要The health-promoting effects of phycocyanin (PC) have become widely accepted over the last two decades. In this study, we investigated the effects of different doses of PC in modulating the intestinal microbiota and the intestinal barrier in mice. Six-week-old male C57BL/6 mice were treated with PC for 28 days. Fecal samples were collected before and after PC intervention, and the microbiota were analyzed by 16S rRNA high-throughput sequencing. Bacterial abundance and diversity increased after PC intervention. Saccharolytic bacteria of the families Lachnospiraceae and Ruminococcaceae, which can produce butyric acid, increased after PC treatment. The family Rikenellaceae, which contains hydrogen-producing bacteria, also increased after PC intervention. The PC treatment reduced intestinal permeability and increased the intestinal barrier function, as demonstrated by hematoxylin-eosin staining and reduced serum lipopolysaccharide levels. The modulating effects on the intestinal microbiota were more favorable in the low-dose PC group.
WOS关键词OXIDATIVE STRESS ; DIET ; LACHNOSPIRACEAE ; SPECIALIZATION ; INFLAMMATION ; ANTIOXIDANT ; DIVERSITY ; BUTYRATE ; ECOLOGY
WOS研究方向Microbiology
语种英语
WOS记录号WOS:000485975100004
源URL[http://ir.yic.ac.cn/handle/133337/24866]  
专题烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
作者单位1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai, Peoples R China;
2.Yantai Univ, Yantai, Peoples R China;
3.Chinese Acad Sci, Inst Proc Engn, Beijing, Peoples R China
推荐引用方式
GB/T 7714		 Xie, YY,Li, WJ,Zhu, LM,et al. Effects of phycocyanin in modulating the intestinal microbiota of mice[J]. MICROBIOLOGYOPEN,2019,8(9):e825.
APA Xie, YY,Li, WJ,Zhu, LM,Zhai, SX,Qin, S,&Du, ZN.(2019).Effects of phycocyanin in modulating the intestinal microbiota of mice.MICROBIOLOGYOPEN,8(9),e825.
MLA Xie, YY,et al."Effects of phycocyanin in modulating the intestinal microbiota of mice".MICROBIOLOGYOPEN 8.9(2019):e825.

入库方式： OAI收割

来源：烟台海岸带研究所

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