Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-kappa B signaling pathway
文献类型：期刊论文
| 作者 | Liu, Q; Li, WJ ; Lu, LN; Liu, B; Du, ZN; Qin, S
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| 刊名 | JOURNAL OF OCEANOLOGY AND LIMNOLOGY
 |
| 出版日期 | 2019-09 |
| 卷号 | 37期号:5页码:1678-1685 |
| ISSN号 | 2096-5508 |
| 关键词 | phycocyanin inflammatory TLR2-MyD88-NF-kappa B signaling pathway |
| DOI | 10.1007/s00343-019-8196-8 |
| 产权排序 | [Liu Qi ; Li Wenjun ; Qin Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China ; [Liu Qi ; Du Zhenning] Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China ; [Lu Lina ; Liu Bin] Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou 730000, Gansu, Peoples R China |
| 文献子类 | Article |
| 英文摘要 | Phycocyanin (PC), a natural algal protein, is reported for having anti-oxidant and antiinflammatory properties. We investigated its ability to attenuate lung inflammation in mice subjected to X-ray radiation. Male C57BL/6 mice were assigned to the control, total body irradiation, PC pretreatment, and PC treatment groups. Mice in the PC pretreatment group were gavaged with 200 mg/kg PC for 7 consecutive days before irradiation, and those in the PC treatment group were gavaged with 200 mg/kg PC for 7 consecutive days after irradiation. Lungs were collected on Day 7 after irradiation exposure. Hematoxylin and eosin staining of mouse lung sections showed considerable inflammation damage 7 days after irradiation compared with the control lung but a reduction in pathological injury in the PC treatment group. Pretreatment or treatment with PC significantly decreased levels of interleukin-6 and tumor necrosis factor-alpha in the lung, and also increased the relative mRNA expression of superoxide dismutase and glutathione. In vivo, PC significantly reduced the expression of Toll-like receptor TLR2, myeloid differentiation primary response Myd88, and nuclear factor NF-kappa B, at both the transcriptional and translation level. Taken together, these data indicated that PC attenuated lung inflammatory damage induced by radiation by blocking the TLR2-MyD88-NF-kappa B signaling pathway. Therefore, PC could be a protective agent against radiation-induced inflammatory damage in normal tissues. |
| WOS关键词 | CELL LUNG-CANCER ; RADIATION PNEUMONITIS ; C-PHYCOCYANIN ; FIBROSIS ; RADIOTHERAPY |
| WOS研究方向 | Limnology ; Oceanography |
| 语种 | 英语 |
| WOS记录号 | WOS:000484533400019 |
| 资助机构 | National Key Research and Development Program of China [2018YFD0901102] |
| 源URL | [http://ir.yic.ac.cn/handle/133337/24869]  |
| 专题 | 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; 2.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China; 3.Lanzhou Univ, Sch Nucl Sci & Technol, Lanzhou 730000, Gansu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Q,Li, WJ,Lu, LN,et al. Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-kappa B signaling pathway[J]. JOURNAL OF OCEANOLOGY AND LIMNOLOGY,2019,37(5):1678-1685. |
| APA | Liu, Q,Li, WJ,Lu, LN,Liu, B,Du, ZN,&Qin, S.(2019).Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-kappa B signaling pathway.JOURNAL OF OCEANOLOGY AND LIMNOLOGY,37(5),1678-1685. |
| MLA | Liu, Q,et al."Phycocyanin attenuates X-ray-induced pulmonary inflammation via the TLR2-MyD88-NF-kappa B signaling pathway".JOURNAL OF OCEANOLOGY AND LIMNOLOGY 37.5(2019):1678-1685. |
入库方式： OAI收割
来源：烟台海岸带研究所
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