Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice
文献类型：期刊论文
| 作者 | Zhai, SX; Qin, S ; Li, LL; Zhu, LM; Zou, ZQ; Wang, L
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| 刊名 | FEMS MICROBIOLOGY LETTERS
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| 出版日期 | 2019-07 |
| 卷号 | 366期号:13页码:fnz153 |
| 关键词 | butyrate gut microbiota inflammation endotoxin SCFAs |
| ISSN号 | 0378-1097 |
| DOI | 10.1093/femsle/fnz153 |
| 产权排序 | [Zhai, Shixiang ; Qin, Song ; Li, Lili] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China ; [Zhai, Shixiang ; Zhu, Limeng] Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China ; [Zhu, Limeng] Chinese Acad Sci, Inst Proc Engn, Beijing 100080, Peoples R China ; [Zou, Zhiqiang ; Wang, Li] Infect Dis Hosp Yantai, Dept Hepatol, Yantai 264001, Peoples R China |
| 文献子类 | Article |
| 英文摘要 | Butyrate, a key metabolite fermented by gut microbiota mainly from undigested carbohydrates such as dietary fibers is widely used as feed additive. However, mechanisms of its contributions in maintaining host health are relatively poorly revealed. The aim of this study was to investigate how butyrate impacts gut microbiota and immunity response in high-fat diet-fed mice. Gut microbial analysis exhibited that butyrate intervention increased short-chain fatty acids (SCFAs)-producing bacteria and decreased pathogenic bacteria, such as endotoxin-secreting bacteria. Our result also demonstrated that butyrate intervention enhanced fecal SCFAs concentrations, and inhibited endotoxin levels in feces and serum. Correlation analysis indicated positive relation between endotoxin level and Desulfovibrionaceae abundance. Furthermore, butyrate intervention inhibited expressions of IL-1 beta, IL-6 and MCP1/CCL2 in liver, as well as TLR4 in adipose tissue. Apart from inhibiting expressions of proinflammatory cytokines, butyrate exerted anti-inflammation effect through selectively modulating gut microbiota, such as increasing SCFAs-producing bacteria and decreasing endotoxin-secreting bacteria, as well as via regulating levels of microbiota-dependent metabolites and components, such as SCFAs and endotoxin. |
| WOS关键词 | OBESITY ; ACIDS |
| WOS研究方向 | Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000493065400004 |
| 资助机构 | Youth Innovation Promotion Association of Chinese Academy of Sciences [2018246] ; National Key Research and Development Program of China [2017YFC0506200] ; National Innovation and Development of Marine Economy Demonstration Area of the City [2016496] |
| 源URL | [http://ir.yic.ac.cn/handle/133337/24902]  |
| 专题 | 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 中国科学院烟台海岸带研究所 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Shandong, Peoples R China; 2.Chinese Acad Sci, Inst Proc Engn, Beijing 100080, Peoples R China; 3.Infect Dis Hosp Yantai, Dept Hepatol, Yantai 264001, Peoples R China 4.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhai, SX,Qin, S,Li, LL,et al. Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice[J]. FEMS MICROBIOLOGY LETTERS,2019,366(13):fnz153. |
| APA | Zhai, SX,Qin, S,Li, LL,Zhu, LM,Zou, ZQ,&Wang, L.(2019).Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice.FEMS MICROBIOLOGY LETTERS,366(13),fnz153. |
| MLA | Zhai, SX,et al."Dietary butyrate suppresses inflammation through modulating gut microbiota in high-fat diet-fed mice".FEMS MICROBIOLOGY LETTERS 366.13(2019):fnz153. |
入库方式： OAI收割
来源：烟台海岸带研究所
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