Alginate oligosaccharide improves lipid metabolism and inflammation by modulating gut microbiota in high-fat diet fed mice
文献类型：期刊论文
| 作者 | Wang, Yuting; Li, Lili ; Ye, Changqing; Yuan, Jingyi; Qin, Song
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| 刊名 | APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
 |
| 出版日期 | 2020-03 |
| 卷号 | 104期号:8页码:3541-3554 |
| 关键词 | LACTOBACILLUS-REUTERI INDUCED OBESITY ATTENUATE HYPERTENSION INSULIN-RESISTANCE ACID RATS ACTIVATION GLUCOSE HUMANS ADULTS |
| DOI | 10.1007/s00253-020-10449-7 |
| 产权排序 | [Wang, Yuting ; Ye, Changqing] Nantong Univ, Sch Publ Hlth, Nantong 226019, Peoples R China ; [Wang, Yuting ; Li, Lili ; Yuan, Jingyi ; Qin, Song] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China ; [Wang, Yuting ; Li, Lili ; Yuan, Jingyi ; Qin, Song] Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China ; [Yuan, Jingyi] Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China |
| 文献子类 | Article |
| 英文摘要 | Alginate oligosaccharides are associated with some beneficial health effects. Gut microbiota is one of the most recently identified factors in the development of several metabolic diseases induced by high-fat diet. Our objective was to evaluate how alginate oligosaccharides impact on high-fat diet-induced features of metabolic disorders and whether this impact is related to modulations in the modulation of the gut microbiota. C57BL/6J mice were fed with chow diet, high-fat diet, or high-fat diet supplemented with alginate oligosaccharides for 10 weeks. Alginate oligosaccharide treatment improved lipid metabolism, such as reducing levels of TG and LDL-C and inhibiting expression of lipogenesis genes. Alginate oligosaccharide administration reduced the levels of fasting blood glucose and increased the levels of serum insulin. Alginate oligosaccharide treatment was found to lower the expression of markers of inflammation, including IL1 beta and CD11c. Alginate oligosaccharide treatment modulated gut microbial communities and markedly prompted the growth of Akkermansia muciniphila, Lactobacillus reuteri, and Lactobacillus gasseri. Additionally, alginate oligosaccharide intervention significantly increased concentrations of short-chain fatty acids, such as acetic acid, propionic acid, and butyric acid, as well as decreased levels of endotoxin. Alginate oligosaccharides exert beneficial effects via alleviating metabolic metrics induced by high-fat diet, which is associated with increase in A. muciniphila, L. reuteri, and L. gasseri, as well as the release of microbiota-dependent short-chain fatty acids and inhibition of endotoxin levels. |
| WOS关键词 | LACTOBACILLUS-REUTERI ; INDUCED OBESITY ; ATTENUATE HYPERTENSION ; INSULIN-RESISTANCE ; ACID ; RATS ; ACTIVATION ; GLUCOSE ; HUMANS ; ADULTS |
| 语种 | 英语 |
| WOS记录号 | WOS:000516798000002 |
| 资助机构 | National Key R&D Program of China [2017YFC0506200] ; Youth Innovation Promotion Association of Chinese Academy of Sciences [2018246] |
| 源URL | [http://ir.yic.ac.cn/handle/133337/25084]  |
| 专题 | 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 作者单位 | 1.Nantong Univ, Sch Publ Hlth, Nantong 226019, Peoples R China; 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; 3.Yantai Univ, Coll Life Sci, Yantai 264005, Peoples R China 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wang, Yuting,Li, Lili,Ye, Changqing,et al. Alginate oligosaccharide improves lipid metabolism and inflammation by modulating gut microbiota in high-fat diet fed mice[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2020,104(8):3541-3554. |
| APA | Wang, Yuting,Li, Lili,Ye, Changqing,Yuan, Jingyi,&Qin, Song.(2020).Alginate oligosaccharide improves lipid metabolism and inflammation by modulating gut microbiota in high-fat diet fed mice.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,104(8),3541-3554. |
| MLA | Wang, Yuting,et al."Alginate oligosaccharide improves lipid metabolism and inflammation by modulating gut microbiota in high-fat diet fed mice".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 104.8(2020):3541-3554. |
入库方式： OAI收割
来源：烟台海岸带研究所
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