Synthesis, Characterization, and Antifungal Property of Hydroxypropyltrimethyl Ammonium Chitosan Halogenated Acetates
文献类型：期刊论文
| 作者 | Mi, Yingqi; Tan, Wenqiang ; Zhang, Jingjing; Wei, Lijie; Chen, Yuan; Li, Qing; Dong, Fang; Guo, Zhanyong
|
| 刊名 | MARINE DRUGS
 |
| 出版日期 | 2018-09 |
| 卷号 | 16期号:9页码:315 |
| 关键词 | hydroxypropyltrimethyl ammonium chloride chitosan halogenated acetate antifungal activity electronegativity |
| ISSN号 | 1660-3397 |
| DOI | 10.3390/md16090315 |
| 产权排序 | [Mi, Yingqi ; Tan, Wenqiang ; Zhang, Jingjing ; Wei, Lijie ; Chen, Yuan ; Li, Qing ; Dong, Fang ; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China ; [Mi, Yingqi ; Tan, Wenqiang ; Zhang, Jingjing ; Wei, Lijie ; Chen, Yuan ; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 文献子类 | Article |
| 英文摘要 | Hydroxypropyltrimethyl ammonium chitosan halogenated acetates were successfully synthesized from six different haloacetic acids and hydroxypropyltrimethyl ammonium chloride chitosan (HACC) with high substitution degree, which are hydroxypropyltrimethyl ammonium chitosan bromacetate (HACBA), hydroxypropyltrimethyl ammonium chitosan chloroacetate (HACCA), hydroxypropyltrimethyl ammonium chitosan dichloroacetate (HACDCA), hydroxypropyltrimethyl ammonium chitosan trichloroacetate (HACTCA), hydroxypropyltrimethyl ammonium chitosan difluoroacetate (HACDFA), and hydroxypropyltrimethyl ammonium chitosan trifluoroacetate (HACTFA). These chitosan derivatives were synthesized by two steps: first, the hydroxypropyltrimethyl ammonium chloride chitosan was synthesized by chitosan and 3-chloro-2-hydroxypropyltrimethyl ammonium chloride. Then, hydroxypropyltrimethyl ammonium chitosan halogenated acetates were synthesized via ion exchange. The structures of chitosan derivatives were characterized by Fourier transform infrared spectroscopy (FTIR), H-1 Nuclear magnetic resonance spectrometer (H-1 NMR), C-13 Nuclear magnetic resonance spectrometer (C-13 NMR), and elemental analysis. Their antifungal activities against Colletotrichum lagenarium, Fusarium graminearum, Botrytis cinerea, and Phomopsis asparagi were investigated by hypha measurement in vitro. The results revealed that hydroxypropyltrimethyl ammonium chitosan halogenated acetates had better antifungal activities than chitosan and HACC. In particular, the inhibitory activity decreased in the order: HACTFA > HACDFA > HACTCA > HACDCA > HACCA > HACBA > HACC > chitosan, which was consistent with the electron-withdrawing property of different halogenated acetates. This experiment provides a potential idea for the preparation of new antifungal drugs by chitosan. |
| WOS关键词 | QUATERNARY AMMONIUM ; ANTIBACTERIAL ACTIVITY ; ANTIMICROBIAL ACTIVITY ; FUSARIUM-GRAMINEARUM ; ANTIOXIDANT ACTIVITY ; CHLORIDE CHITOSAN ; SPECIES COMPLEX ; IN-VITRO ; DERIVATIVES ; NANOPARTICLES |
| WOS研究方向 | Chemistry, Medicinal |
| 语种 | 英语 |
| WOS记录号 | WOS:000445636600026 |
| 资助机构 | National Natural Science Foundation of China [41576156] ; Shandong Province Science and Technology Development Plan [2015GSF121045] ; Yantai Science and Technology Development Plan [2015ZH078] ; Technology Research Funds Projects of Ocean [2015418022-3] |
| 源URL | [http://ir.yic.ac.cn/handle/133337/24523]  |
| 专题 | 海岸带生物资源高效利用研究与发展中心 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 烟台海岸带研究所_污染过程与控制实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Mi, Yingqi,Tan, Wenqiang,Zhang, Jingjing,et al. Synthesis, Characterization, and Antifungal Property of Hydroxypropyltrimethyl Ammonium Chitosan Halogenated Acetates[J]. MARINE DRUGS,2018,16(9):315. |
| APA | Mi, Yingqi.,Tan, Wenqiang.,Zhang, Jingjing.,Wei, Lijie.,Chen, Yuan.,...&Guo, Zhanyong.(2018).Synthesis, Characterization, and Antifungal Property of Hydroxypropyltrimethyl Ammonium Chitosan Halogenated Acetates.MARINE DRUGS,16(9),315. |
| MLA | Mi, Yingqi,et al."Synthesis, Characterization, and Antifungal Property of Hydroxypropyltrimethyl Ammonium Chitosan Halogenated Acetates".MARINE DRUGS 16.9(2018):315. |
入库方式： OAI收割
来源：烟台海岸带研究所
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