中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 烟台海岸带研究所
  3. 中国科学院烟台海岸带研究所
  4. 海岸带生物学与生物资源利用重点实验室
  5. 海岸带生物资源高效利用研究与发展中心
Radical Scavenging Activities of Novel Cationic Inulin Derivatives

文献类型：期刊论文

作者Chen, Yuan; Mi, Yingqi; Zhang, Jingjing; Dong, Fang; Li, Qing; Ji, Naiyun; Guo, Zhanyong
刊名POLYMERS
出版日期2018-12
卷号10期号:12页码:1295
关键词cationic inulin derivatives free radicals radical scavenging activity amino-pyridine group
ISSN号2073-4360
DOI10.3390/polym10121295
产权排序[Chen, Yuan ; Mi, Yingqi ; Zhang, Jingjing ; Dong, Fang ; Li, Qing ; Ji, Naiyun ; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China ; [Chen, Yuan ; Mi, Yingqi ; Zhang, Jingjing ; Ji, Naiyun ; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
文献子类Article
英文摘要Many saccharides are attractive targets for biomaterial applications, due to their abundance, biocompatibility, and biodegradability. In this article, a synthesis process of 6-N-substituted cationic inulin derivatives, including 6-pyridyl-6-deoxyinulin bromide (PIL), 6-(2-amino-pyridyl)-6-deoxyinulin bromide (2APIL), 6-(3-amino-pyridyl)-6-deoxyinulin bromide (3APIL), 6-(4-amino-pyridyl)-6-deoxyinulin bromide (4APIL), 6-(2,3-diamino-pyridyl)-6-deoxyinulin bromide (2,3DAPIL), 6-(3,4-diamino-pyridyl)-6-deoxyinulin bromide (3,4DAPIL), and 6-(2,6-diamino-pyridyl)-6-deoxyinulin bromide (2,6DAPIL) was described. The C-6-OH of inulin was first activated by PPh3/N-bromosuccinimide (NBS) bromination. Then, pyridine and different kinds of amino-pyridine groups (different position and different numbers of amino) were grafted onto inulin, respectively, via nucleophilic substitution. Then, we confirmed their structure by Fourier transform infrared spectroscopy (FT-IR) and nuclear magnetic resonance (NMR) spectroscopy. After this, their radical scavenging activities against hydroxyl radical and diphenylpicryl phenylhydrazine (DPPH) radical were tested in vitro. Each derivative showed a distinct improvement in radical scavenging activity when compared to inulin. The hydroxyl-radical scavenging effect decreased in the following order: 3APIL > PIL > 3,4DAPIL > 4APIL > 2,3DAPIL > 2,6DAPIL > 2APIL. Amongst them, 3APIL revealed the most powerful scavenging effect on hydroxyl radicals, as well as DPPH radicals. At 1.6 mg/mL, it could completely eliminate hydroxyl radicals and could clear 65% of DPPH radicals. The results also showed that the steric hindrance effect and the substitute position of the amino group had an effect on the radical scavenging activity. Moreover, the application prospects of inulin derivatives as natural antioxidant biomaterials are scientifically proven in this paper.
WOS关键词ANTIOXIDANT ACTIVITIES ; ANTIMICROBIAL ACTIVITY ; CHEMICAL-MODIFICATIONS ; CHITOSAN ; ANTIBACTERIAL ; FLOCCULANTS ; PEPTIDES ; KINETICS
WOS研究方向Polymer Science
语种英语
WOS记录号WOS:000454748700003
资助机构National Natural Science Foundation of China [41576156] ; Natural Science Foundation of Shandong Province of China [ZR2017BD015] ; Yantai Science and Technology Development Plan [2015ZH078] ; Technology Research Funds Projects of Ocean [2015418022-3]
源URL[http://ir.yic.ac.cn/handle/133337/24597]  
专题海岸带生物资源高效利用研究与发展中心
烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
烟台海岸带研究所_污染过程与控制实验室
作者单位1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China;
推荐引用方式
GB/T 7714		 Chen, Yuan,Mi, Yingqi,Zhang, Jingjing,et al. Radical Scavenging Activities of Novel Cationic Inulin Derivatives[J]. POLYMERS,2018,10(12):1295.
APA Chen, Yuan.,Mi, Yingqi.,Zhang, Jingjing.,Dong, Fang.,Li, Qing.,...&Guo, Zhanyong.(2018).Radical Scavenging Activities of Novel Cationic Inulin Derivatives.POLYMERS,10(12),1295.
MLA Chen, Yuan,et al."Radical Scavenging Activities of Novel Cationic Inulin Derivatives".POLYMERS 10.12(2018):1295.

入库方式： OAI收割

来源：烟台海岸带研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。