Enhanced antioxidant and antifungal activity of chitosan derivatives bearing 6-O-imidazole-based quaternary ammonium salts
文献类型：期刊论文
| 作者 | Wei, Lijie; Li, Qing ; Chen, Yuan; Zhang, Jingjing; Mi, Yingqi; Dong, Fang; Lei, Chunqing; Guo, Zhanyong
|
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2019-02-15 |
| 卷号 | 206页码:493-503 |
| 关键词 | Chitosan Antioxidant activity Antifungal activity Imidazole Quaternary |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2018.11.022 |
| 产权排序 | [Wei, Lijie ; Li, Qing ; Chen, Yuan ; Zhang, Jingjing ; Mi, Yingqi ; Dong, Fang ; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China ; [Wei, Lijie ; Chen, Yuan ; Zhang, Jingjing ; Mi, Yingqi ; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Lei, Chunqing] Yantai Univ, Sch Chem & Chem Engn, Yantai 264005, Peoples R China |
| 文献子类 | Article |
| 英文摘要 | In this paper, a series of 6-O-imidazole-based quaternary ammonium chitosan derivatives via 6-O-chloroacetyl chitosan (CAClC) were successfully designed and synthesized. Detailed structural characterization was carried out by means of FTIR and H-1 NMR spectroscopy, and elemental analysis. Furthermore, the antioxidant property against hydroxyl radicals, superoxide radicals, and DPPH radicals was evaluated in vitro. 2-(N,N,N-trimethyl)-6-O-(2-aminobenzimidazole)acetyl chitosan chloride (2NPhMC) and 2-(N,N,N-trimethyl)-6-O-(1-butylimidazole) acetyl chitosan chloride (NBMC) showed more than 90% scavenging indices at 1.6 mg/mL. Besides, the antifungal activity against Botrytis cinerea and Gibberella zeae was estimated using in vitro MIC and hypha measurements. Most of the quaternized chitosan derivatives especially with the long length alkyl chain and primary amino group showed an inhibitory index of > 85% at 1.0 mg/mL against Botrytis cinerea. Besides, the cytotoxicity of chitosan and all the quaternized chitosan derivatives was evaluated in vitro on HaCaT cells and all the quaternized chitosan derivatives bearing 6-O-imidazole exhibited low cytotoxicity. These results suggested that chitosan derivatives bearing 6-O-imidazole-based quaternary ammonium salts may be used as good biomaterials. |
| WOS关键词 | MEMBRANE-LIPID MONOLAYERS. ; N-SUBSTITUTED CHITOSAN ; ANTIMICROBIAL ACTIVITY ; SUBPHASE DISTURBANT ; SCAVENGING ACTIVITY ; STARCH DERIVATIVES ; ANTIBACTERIAL ; DESIGN ; TEMPERATURE ; ANTITUMOR |
| WOS研究方向 | Chemistry, Applied ; Chemistry, Organic ; Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000452982700056 |
| 资助机构 | National Natural Science Foundation of China [41576156] ; seed project of Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences [YIC Y755031011] ; Natural Science Foundation of Shandong Province of China [ZR 2017BD015] ; Science and Technology Service Network Initiative of Chinese Academy of sciences [KFJ-STSZDTP-023] |
| 源URL | [http://ir.yic.ac.cn/handle/133337/24637]  |
| 专题 | 海岸带生物资源高效利用研究与发展中心 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 烟台海岸带研究所_污染过程与控制实验室 |
| 作者单位 | 1.Yantai Univ, Sch Chem & Chem Engn, Yantai 264005, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China; 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Wei, Lijie,Li, Qing,Chen, Yuan,et al. Enhanced antioxidant and antifungal activity of chitosan derivatives bearing 6-O-imidazole-based quaternary ammonium salts[J]. CARBOHYDRATE POLYMERS,2019,206:493-503. |
| APA | Wei, Lijie.,Li, Qing.,Chen, Yuan.,Zhang, Jingjing.,Mi, Yingqi.,...&Guo, Zhanyong.(2019).Enhanced antioxidant and antifungal activity of chitosan derivatives bearing 6-O-imidazole-based quaternary ammonium salts.CARBOHYDRATE POLYMERS,206,493-503. |
| MLA | Wei, Lijie,et al."Enhanced antioxidant and antifungal activity of chitosan derivatives bearing 6-O-imidazole-based quaternary ammonium salts".CARBOHYDRATE POLYMERS 206(2019):493-503. |
入库方式： OAI收割
来源：烟台海岸带研究所
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