Synthesis, Characterization, and Antioxidant Evaluation of Novel Pyridylurea-Functionalized Chitosan Derivatives
文献类型：期刊论文
| 作者 | Zhang, JJ; Tan, WQ ; Wei, LJ; Dong, F; Li, Q; Guo, ZY
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| 刊名 | POLYMERS
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| 出版日期 | 2019-06 |
| 卷号 | 11期号:6页码:951 |
| 关键词 | antioxidant ability chitosan derivatives pyridylurea |
| DOI | 10.3390/polym11060951 |
| 产权排序 | [Zhang, Jingjing ; Tan, Wenqiang ; Wei, Lijie ; Dong, Fang ; Li, Qing ; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China ; [Zhang, Jingjing ; Tan, Wenqiang ; Wei, Lijie ; Dong, Fang ; Li, Qing ; Guo, Zhanyong] Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China ; [Zhang, Jingjing ; Wei, Lijie ; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 文献子类 | Article |
| 英文摘要 | In order to improve the bioactivity of chitosan, we synthesized a novel series of chitosan derivatives: firstly, chitosan was reacted with methylclhlorofonmate obtaining N-methoxyformylated chitosan (1), which was then converted into N-pyridylurea chitosan derivatives (2a-2c) by amine-ester exchange reaction. In addition, N-pyridylurea chitosan derivatives were conducted by reacting with iodomethane to obtain quaternized N-pyridylurea chitosan derivatives (3a-3c). The structural characteristics of as-prepared chitosan derivatives were confirmed by fourier transform infrared (FT-IR), H-1 nuclear magnetic resonance (H-1 NMR), elemental analysis, and scanning electron microscope (SEM). Meanwhile, the antioxidant activity of the chitosan derivatives was assessed in vitro. As shown in this paper, the antioxidant activity decreased in the order: c > b > a. Moreover, after the quaternization with iodomethane, quaternized N-pyridylurea chitosan derivatives immediately exhibited enhanced antioxidant capacity compared with N-pyridylurea chitosan derivatives. For example, in 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay, the scavenging activities of 3a-3c were 91.75%, 93.63%, and 97.63% while 2a-2c were 42.32%, 42.97%, and 43.07% at 0.4 mg/mL. L929 cells were also adopted for cytotoxicity test of chitosan and synthesized derivatives by CCK-8 assay and all samples showed decreased cytotoxicity. These results suggested that the novel pyridylurea-functionalized chitosan derivatives could be an ideal biomaterial. |
| WOS关键词 | INULIN DERIVATIVES ; STARCH DERIVATIVES ; ANTIFUNGAL ; UREA ; NANOPARTICLES ; PROPERTY ; AGENTS |
| WOS研究方向 | Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000473819100023 |
| 资助机构 | National Natural Science Foundation of ChinaNational Natural Science Foundation of China [41576156] ; Natural Science Foundation of Shandong Province of ChinaNatural Science Foundation of Shandong Province [ZR2017BD015] ; Science and Technology Service Network Initiative of Chinese Academy of Sciences [KFJ-STS-ZDTP-023] ; Public Science and Technology Research Funds Projects of Ocean [2015418022-3] ; Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences [YIC Y755031011] ; Marine public welfare industry research project [Y51Z011011] |
| 源URL | [http://ir.yic.ac.cn/handle/133337/24928]  |
| 专题 | 海岸带生物资源高效利用研究与发展中心 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Shandong, Peoples R China; 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Zhang, JJ,Tan, WQ,Wei, LJ,et al. Synthesis, Characterization, and Antioxidant Evaluation of Novel Pyridylurea-Functionalized Chitosan Derivatives[J]. POLYMERS,2019,11(6):951. |
| APA | Zhang, JJ,Tan, WQ,Wei, LJ,Dong, F,Li, Q,&Guo, ZY.(2019).Synthesis, Characterization, and Antioxidant Evaluation of Novel Pyridylurea-Functionalized Chitosan Derivatives.POLYMERS,11(6),951. |
| MLA | Zhang, JJ,et al."Synthesis, Characterization, and Antioxidant Evaluation of Novel Pyridylurea-Functionalized Chitosan Derivatives".POLYMERS 11.6(2019):951. |
入库方式： OAI收割
来源：烟台海岸带研究所
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