Significantly enhanced antioxidant activity of chitosan through chemical modification with coumarins
文献类型：期刊论文
| 作者 | Li, Q ; Wei, LJ; Zhang, JJ; Gu, GD; Guo, ZY
|
| 刊名 | POLYMER CHEMISTRY
 |
| 出版日期 | 2019-03-28 |
| 卷号 | 10期号:12页码:1480-1488 |
| 关键词 | RADICAL-SCAVENGING ACTIVITY QUATERNIZED CHITOSAN INULIN DERIVATIVES PROPERTY |
| ISSN号 | 1759-9954 |
| DOI | 10.1039/c8py01790e |
| 产权排序 | [Li, Qing ; Wei, Lijie ; Zhang, Jingjing ; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China ; [Wei, Lijie ; Zhang, Jingjing] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China ; [Gu, Guodong] Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA |
| 文献子类 | Article |
| 英文摘要 | A new class of chitosan derivatives possessing coumarins was synthesized to improve the antioxidant activity of chitosan. Their antioxidant properties were tested, including the inhibition of lipid peroxidation activity, metal ion chelating ability, and free radical-scavenging activity. Base on the value of IC50, the inhibitory property of the synthesized chitosan derivatives exhibited a remarkable improvement over chitosan. The IC50 of the inhibition of lipid peroxidation, iron-chelation, and hydroxyl ((OH)-O-center dot) radical-scavenging was 0.11-0.13, 0.02-0.04, and 0.09-0.14 mg mL(-1), respectively. The chelation of iron and the scavenging of superoxide radicals could affect the scavenging of (OH)-O-center dot, which in turn affects the inhibition of lipid peroxidation. In the cytotoxicity assay, no cytotoxicity was observed for the 3T3-L1 and HHL-5 cells incubated with chitosan and its derivatives at all the testing concentrations. Meanwhile, the synthesized chitosan derivatives could prompt the 3T3-L1 cell growth, which should be related to their high antioxidant activity. These results demonstrated that the combination of chitosan and coumarins improved the antioxidant activity of chitosan obviously, and the antioxidants or free radical scavengers based on natural polymers and coumarins showed potential applications. |
| WOS关键词 | RADICAL-SCAVENGING ACTIVITY ; QUATERNIZED CHITOSAN ; INULIN DERIVATIVES ; PROPERTY |
| WOS研究方向 | Polymer Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000462077800007 |
| 资助机构 | Natural Science Foundation of Shandong Province of ChinaNatural Science Foundation of Shandong Province [ZR2017BD015] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [41576156] ; Technology Research Funds Projects of Ocean [2015418022-3] |
| 源URL | [http://ir.yic.ac.cn/handle/133337/24972]  |
| 专题 | 海岸带生物资源高效利用研究与发展中心 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 作者单位 | 1.Alliance Pharma Inc, 17 Lee Blvd, Malvern, PA 19355 USA 2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China; 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shangdong, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Li, Q,Wei, LJ,Zhang, JJ,et al. Significantly enhanced antioxidant activity of chitosan through chemical modification with coumarins[J]. POLYMER CHEMISTRY,2019,10(12):1480-1488. |
| APA | Li, Q,Wei, LJ,Zhang, JJ,Gu, GD,&Guo, ZY.(2019).Significantly enhanced antioxidant activity of chitosan through chemical modification with coumarins.POLYMER CHEMISTRY,10(12),1480-1488. |
| MLA | Li, Q,et al."Significantly enhanced antioxidant activity of chitosan through chemical modification with coumarins".POLYMER CHEMISTRY 10.12(2019):1480-1488. |
入库方式： OAI收割
来源：烟台海岸带研究所
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