Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications
文献类型：期刊论文
| 作者 | Qin, Yukun; Li, Pengcheng; Guo, Zhanyong
|
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2020-05-15 |
| 卷号 | 236页码:116002 |
| 关键词 | CANDIDA-ALBICANS BIOFILMS N-PHTHALOYL-CHITOSAN OF-THE-ART ANTIBACTERIAL ACTIVITY ANTIMICROBIAL ACTIVITY QUATERNIZED CHITOSAN DRUG-DELIVERY EDIBLE FILMS IN-VITRO DIETHYLAMINOETHYL CHITOSAN |
| DOI | 10.1016/j.carbpol.2020.116002 |
| 产权排序 | [Qin, Yukun ; Li, Pengcheng] Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Key Lab Expt Marine Biol, Qingdao, Peoples R China ; [Qin, Yukun ; Li, Pengcheng] Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China ; [Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China |
| 文献子类 | Review |
| 英文摘要 | The increasing resistance of pathogen fungi poses a global public concern. There are several limitations in current antifungals, including few available fungicides, severe toxicity of some fungicides, and drug resistance. Therefore, there is an urgent need to develop new antifungals with novel targets. Chitosan has been recognized as a potential antifungal substance due to its good biocompatibility, biodegradability, non-toxicity, and availability in abundance, but its applications are hampered by the low charge density results in low solubility at physiological pH. It is believed that enhancing the positive charge density of chitosan may be the most effective approach to improve both its solubility and antifungal activity. Hence, this review mainly focuses on the structural optimization strategy of cationic chitosan and the potential antifungal applications. This review also assesses and comments on the challenges, shortcomings, and prospect of cationic chitosan derivatives as antifungal therapy. |
| WOS关键词 | CANDIDA-ALBICANS BIOFILMS ; N-PHTHALOYL-CHITOSAN ; OF-THE-ART ; ANTIBACTERIAL ACTIVITY ; ANTIMICROBIAL ACTIVITY ; QUATERNIZED CHITOSAN ; DRUG-DELIVERY ; EDIBLE FILMS ; IN-VITRO ; DIETHYLAMINOETHYL CHITOSAN |
| 语种 | 英语 |
| WOS记录号 | WOS:000519306900012 |
| 资助机构 | National Key R&D Program of China [2018YFC0311305, 2019YFD0900705] ; Key Research and Development Program of Shandong Province [2018GHY115017] ; Qingdao Applied Basic Research Project [19-6-2-34-cg] ; Science and technology program of Nantong [MS120170234] |
| 源URL | [http://ir.yic.ac.cn/handle/133337/25034]  |
| 专题 | 海岸带生物资源高效利用研究与发展中心 烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China; 3.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Key Lab Expt Marine Biol, Qingdao, Peoples R China; |
| 推荐引用方式 GB/T 7714 | Qin, Yukun,Li, Pengcheng,Guo, Zhanyong. Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications[J]. CARBOHYDRATE POLYMERS,2020,236:116002. |
| APA | Qin, Yukun,Li, Pengcheng,&Guo, Zhanyong.(2020).Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications.CARBOHYDRATE POLYMERS,236,116002. |
| MLA | Qin, Yukun,et al."Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications".CARBOHYDRATE POLYMERS 236(2020):116002. |
入库方式： OAI收割
来源：烟台海岸带研究所
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