Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys
文献类型：期刊论文
| 作者 | Chen G3; Qian H3; Starz T*4; Sun HT5; Garcia B5; Wang XM3; Wise Y3; Liu YQ3; Xiang Y; Copeman L6 |
| 刊名 | NATURE MEDICINE
 |
| 出版日期 | 2005 |
| 卷号 | 11期号:12页码:1295-1298 |
| ISSN号 | 1078-8956 |
| 英文摘要 | We transplanted kidneys from alpha 1,3-galactosyltransferase knockout (GalT-KO) pigs into six baboons using two different immunosuppressive regimens, but most of the baboons died from severe acute humoral xenograft rejection. Circulating induced antibodies to non-Gal antigens were markedly elevated at rejection, which mediated strong complement-dependent cytotoxicity against GaIT-KO porcine target cells. These data suggest that antibodies to non-Gal antigens will present an additional barrier to transplantation of organs from GaIT-KO pigs to humans. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/2685]  |
| 专题 | 昆明动物研究所_其他 |
| 通讯作者 | mangantl@upmc.edu |
| 作者单位 | 1.London Hlth Sci Ctr, Lawson Hlth Res Inst, London, ON N6A 5A5, Canada 2.Univ Western Ontario, Dept Microbiol & Immunol, London, ON N6A 5C1, Canada 3.Univ Western Ontario, Dept Surg, London, ON N6A 5C1, Canada 4.Univ Pittsburgh, Ctr Med, Thomas E Starzl Transplantat Inst, Pittsburgh, PA 15213 USA 5.Univ Western Ontario, Dept Pathol, London, ON N6A 5A5, Canada 6.Robarts Res Inst, Transplantat Grp, London, ON N6A 5C1, Canada 7.Univ Western Ontario, Dept Med, London, ON N6A 5A5, Canada 8.London Hlth Sci Ctr, Multi Organ Transplant Program, London, ON N6A 5A5, Canada 9.Revivcor Inc, Blacksburg, VA 24060 USA 10.Chinese Acad Sci, Kunming Inst Zool, Anim Toxicol Lab, Kunming, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen G,Qian H,Starz T*,et al. Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys[J]. NATURE MEDICINE,2005,11(12):1295-1298. |
| APA | Chen G.,Qian H.,Starz T*.,Sun HT.,Garcia B.,...&mangantl@upmc.edu.(2005).Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys.NATURE MEDICINE,11(12),1295-1298. |
| MLA | Chen G,et al."Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys".NATURE MEDICINE 11.12(2005):1295-1298. |
入库方式： OAI收割
来源：昆明动物研究所
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