Prolonged cardiac xenograft survival in guinea pig-to-rat model by a highly active cobra venom factor
文献类型：期刊论文
| 作者 | Sun QY*2; Chen G1; Guo H1; Chen S1; Wang WY2; Xiong YL2; sunqy@hotmail.com |
| 刊名 | TOXICON
 |
| 出版日期 | 2003 |
| 卷号 | 42期号:3页码:257-262 |
| 关键词 | Cobra Venom Factor Complement Guinea Pig-to-rat Model Heart Transplantation Xenotransplantation |
| ISSN号 | 0041-0101 |
| 英文摘要 | A highly active cobra venom factor (CVF) was isolated from the venom of Naja kaouthia by sequential column chromatography. It displays strong anticomplementary activity, and has 1515 U of anticomplementary activity per mg protein. A single dose of 0.1 mg/kg CVF given i.v. to rats completely abrogated complement activity for nearly 5 days. Given 0.02 mg/kg of CVF, the complement activity of rats was reduced by more than 96.5% in 6 h. In guinea pig-to-rat heart transplant model, rats treated with a single dose of 0.05 mg/kg CVF had significantly prolonged xenograft survival (56.12+/-6.27 h in CVF-treated rats vs. 0.19+/-0.07 h in control rats, P<0.001). |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5269]  |
| 专题 | 昆明动物研究所_其他 |
| 通讯作者 | sunqy@hotmail.com |
| 作者单位 | 1.Institute of Organ Transplantation, the Affiliated Tongji Hospital, Tongji Medical college, Huazhong University of Science and Technology, Wuhan 430030, China 2.Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China |
| 推荐引用方式 GB/T 7714 | Sun QY*,Chen G,Guo H,et al. Prolonged cardiac xenograft survival in guinea pig-to-rat model by a highly active cobra venom factor[J]. TOXICON,2003,42(3):257-262. |
| APA | Sun QY*.,Chen G.,Guo H.,Chen S.,Wang WY.,...&sunqy@hotmail.com.(2003).Prolonged cardiac xenograft survival in guinea pig-to-rat model by a highly active cobra venom factor.TOXICON,42(3),257-262. |
| MLA | Sun QY*,et al."Prolonged cardiac xenograft survival in guinea pig-to-rat model by a highly active cobra venom factor".TOXICON 42.3(2003):257-262. |
入库方式： OAI收割
来源：昆明动物研究所
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