In vitro activities of small peptides from snake venom against clinical isolates of drug-resistant Mycobacterium tuberculosis
文献类型：期刊论文
| 作者 | Xie JP1,4; Yue J3,4; Xiong YL2; Wang WY2; Yu SQ4; Wang HH*4; jianpingxie@yahoo.com |
| 刊名 | INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
 |
| 出版日期 | 2003 |
| 卷号 | 22期号:2页码:172-174 |
| 关键词 | Mycobacterium Tuberculosis Multidrug Resistance Snake Venom Small Peptide Naja Atra |
| ISSN号 | 0924-8579 |
| 英文摘要 | The recent re-emergence of tuberculosis, especially the multidrug-resistant cases, has highlighted the importance of screening effective novel drugs against Mycobacterium tuberculosis. In this study, the in vitro activities of small peptides isolated from snake venom were investigated against multidrug-resistant M. tuberculosis. Minimum inhibitory concentrations (MICs) were determined by the Bactec TB-460 radiometric method. A small peptide with the amino acid sequence ECYRKSDIVTCEPWQKFCYREVTFFPNHPVYLSGCASECTETNSKWCCTTDKCNRARGG (designated as vgf-1) from Naja atra (isolated from Yunnan province of China) venom had in vitro activity against clinically isolated multidrug-resistant strains of M. tuberculosis. The MIC was 8.5 mg/l. The antimycobacterial domain of this 60aa peptide is under investigation. (C) 2003 Elsevier Science B.V. and the International Society of Chemotherapy. All rights reserved. |
| URL标识 | 查看原文 |
| 语种 | 英语 |
| 资助机构 | The study was funded by the National 10th Five-year Key Project (2001DA705D03). ; The study was funded by the National 10th Five-year Key Project (2001DA705D03). ; The study was funded by the National 10th Five-year Key Project (2001DA705D03). ; The study was funded by the National 10th Five-year Key Project (2001DA705D03). |
| 公开日期 | 2010-08-24 |
| 源URL | [http://159.226.149.42:8088/handle/152453/5271]  |
| 专题 | 昆明动物研究所_其他 |
| 通讯作者 | jianpingxie@yahoo.com |
| 作者单位 | 1.School of Life Science, Institute of Modern Biopharmaceuticals, Southwest Normal University, Chongqing 400715, People’s Republic of China 2.Laboratory of Animal Toxin, Kunming Institute of Zoology, Kunming 650223, People’s Republic of China 3.Shanghai Pulmonary Hospital, Shanghai 200433, People’s Republic of China 4.School of Life Science, Institute of Genetics, Fudan University, Shanghai 200433, People’s Republic of China |
| 推荐引用方式 GB/T 7714 | Xie JP,Yue J,Xiong YL,et al. In vitro activities of small peptides from snake venom against clinical isolates of drug-resistant Mycobacterium tuberculosis[J]. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS,2003,22(2):172-174. |
| APA | Xie JP.,Yue J.,Xiong YL.,Wang WY.,Yu SQ.,...&jianpingxie@yahoo.com.(2003).In vitro activities of small peptides from snake venom against clinical isolates of drug-resistant Mycobacterium tuberculosis.INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS,22(2),172-174. |
| MLA | Xie JP,et al."In vitro activities of small peptides from snake venom against clinical isolates of drug-resistant Mycobacterium tuberculosis".INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 22.2(2003):172-174. |
入库方式： OAI收割
来源：昆明动物研究所
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