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Experimental Evaluation on the Heating Efficiency of Magnetoferritin Nanoparticles in an Alternating Magnetic Field

文献类型：期刊论文

作者Xu, Huangtao1,2,3; Pan, Yongxin1,2,3
刊名NANOMATERIALS
出版日期2019-10-01
卷号9期号:10页码:14
关键词magnetic nanoparticles magnetic hyperthermia magentoferritin Neel relaxation specific loss power intrinsic loss power
DOI10.3390/nano9101457
英文摘要The superparamagnetic substance magnetoferritin is a potential bio-nanomaterial for tumor magnetic hyperthermia because of its active tumor-targeting outer protein shell, uniform and tunable nanosized inner mineral core, monodispersity and good biocompatibility. Here, we evaluated the heating efficiency of magnetoferritin nanoparticles in an alternating magnetic field (AMF). The effects of core-size, Fe concentration, viscosity, and field frequency and amplitude were investigated. Under 805.5 kHz and 19.5 kA/m, temperature rise (Delta T) and specific loss power (SLP) measured on magnetoferritin nanoparticles with core size of 4.8 nm at 5 mg/mL were 14.2 degrees C (at 6 min) and 68.6 W/g, respectively. The SLP increased with core-size, Fe concentration, AMF frequency, and amplitude. Given that: (1) the SLP was insensitive to viscosity of glycerol-water solutions and (2) both the calculated effective relaxation time and the fitted relaxation time were closer to Neel relaxation time, we propose that the heating generation mechanism of magnetoferritin nanoparticles is dominated by the Neel relaxation. This work provides new insights into the heating efficiency of magnetoferritin and potential future applications for tumor magnetic hyperthermia treatment and heat-triggered drug release.
WOS关键词CANCER-TREATMENT ; LOSS POWER ; HYPERTHERMIA ; FERRITIN ; OXIDE ; CELLS ; FLUID ; SIZE
资助项目National Natural Science Foundation of China[41621004] ; Key Program of Chinese Academy of Sciences[QYZDJ-SSW-DQC024]
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000495666800112
出版者MDPI
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences
源URL[http://ir.iggcas.ac.cn/handle/132A11/95696]  
专题地质与地球物理研究所_中国科学院地球与行星物理重点实验室
通讯作者Pan, Yongxin
作者单位1.Chinese Acad Sci, Inst Geol & Geophys, Key Lab Earth & Planetary Phys, Biogeomagnetism Grp,Paleomagnetism & Geochronol L, Beijing 100029, Peoples R China
2.Chinese Acad Sci, Inst Earth Sci, Beijing 100029, Peoples R China
3.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Xu, Huangtao,Pan, Yongxin. Experimental Evaluation on the Heating Efficiency of Magnetoferritin Nanoparticles in an Alternating Magnetic Field[J]. NANOMATERIALS,2019,9(10):14.
APA Xu, Huangtao,&Pan, Yongxin.(2019).Experimental Evaluation on the Heating Efficiency of Magnetoferritin Nanoparticles in an Alternating Magnetic Field.NANOMATERIALS,9(10),14.
MLA Xu, Huangtao,et al."Experimental Evaluation on the Heating Efficiency of Magnetoferritin Nanoparticles in an Alternating Magnetic Field".NANOMATERIALS 9.10(2019):14.

入库方式： OAI收割

来源：地质与地球物理研究所

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