Perfluorobutanesulfonate Exposure Skews Sex Ratio in Fish and Transgenerationally Impairs Reproduction.
文献类型：期刊论文
| 作者 | Chen, Lianguo; Lam, James C.W.; Hu, Chenyan; Tsui, Mirabelle M.P.; Lam, Paul K.S.; Zhou, Bingsheng |
| 刊名 | Environmental Science & Technology
 |
| 出版日期 | 2019-07-16 |
| 卷号 | 53期号:14页码:8389-8397 |
| ISSN号 | 0013-936X |
| 英文摘要 | Perfluorobutanesulfonate (PFBS) is increasingly polluting aquatic environments due to worldwide manufacturing and application. However, toxicological knowledge regarding PFBS exposure remains scarce. Here, we showed that PFBS life-cycle exposure at environmentally realistic concentrations (0, 1.0, 2.9, and 9.5 [mu]g/L) skewed the sex ratio in fish toward male dominance, while reproductive functions of female fish were greatly impaired, as characterized by extremely small ovaries, blocked oocyte development, and decreased egg production. Endocrine disruption through the hypothalamus-pituitary-gonad axis was induced by PFBS exposure, showing antiestrogenic activity in females but estrogenic activity in males. PFBS was found to gradually accumulate in F0 adults during continuous exposure but can be rapidly eliminated when depurated in clean water. Parental exposure also transferred PFBS pollutant to F1 offspring eggs. Although no trace of PFBS was detected in F1 adults and F2 eggs, adverse effects from parental exposure persisted in F1 and F2 offspring. These transgenerational effects implicate PFBS as an ongoing threat to the fitness and sustainability of fish populations. The dramatic impairment of fish reproduction highlights the urgency of re-evaluations of the ecological and evolutionary consequences of PFBS exposure. |
| WOS研究方向 | Zoology ; Physiology ; Endocrinology & Metabolism ; Reproductive Biology ; Developmental Biology ; Genetics & Heredity ; Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:ZOOR15512082122 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/35253]  |
| 专题 | 水生生物研究所_水环境工程研究中心_期刊论文 |
| 作者单位 | Chinese Acad Sci, Inst Hydrobiol, Wuhan, Hubei, 430072, China |
| 推荐引用方式 GB/T 7714 | Chen, Lianguo,Lam, James C.W.,Hu, Chenyan,et al. Perfluorobutanesulfonate Exposure Skews Sex Ratio in Fish and Transgenerationally Impairs Reproduction.[J]. Environmental Science & Technology,2019,53(14):8389-8397. |
| APA | Chen, Lianguo,Lam, James C.W.,Hu, Chenyan,Tsui, Mirabelle M.P.,Lam, Paul K.S.,&Zhou, Bingsheng.(2019).Perfluorobutanesulfonate Exposure Skews Sex Ratio in Fish and Transgenerationally Impairs Reproduction..Environmental Science & Technology,53(14),8389-8397. |
| MLA | Chen, Lianguo,et al."Perfluorobutanesulfonate Exposure Skews Sex Ratio in Fish and Transgenerationally Impairs Reproduction.".Environmental Science & Technology 53.14(2019):8389-8397. |
入库方式： OAI收割
来源：水生生物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。