Bioconcentration, Biotransformation, and Thyroid Endocrine Disruption of Decabromodiphenyl Ethane (Dbdpe), A Novel Brominated Flame Retardant, in Zebrafish Larvae.
文献类型：期刊论文
| 作者 | Wang, Xiaochen; Ling, Siyuan; Guan, Kelan; Luo, Xiaojun; Chen, Lianguo; Han, Jian; Zhang, Wei; Mai, Bixian; Zhou, Bingsheng |
| 刊名 | Environmental Science & Technology
 |
| 出版日期 | 2019-07-16 |
| 卷号 | 53期号:14页码:8437-8446 |
| ISSN号 | 0013-936X |
| 英文摘要 | The brominated flame retardant decabromodior phenyl ethane (DBDPE), an alternative to decabrominated diphenyl ether (BDE209), has become a widespread environmental contaminant, but its possible toxic effects to wildlife remain unknown. Using zebrafish as a model, we investigated the bioconcentration and impact of DBDPE on thyroid endocrine function after water-borne exposure, compared to BDE209. Zebrafish embryos were exposed to DBDPE or BDE209 (0, 3, 10, 30, 100, 300 nM) for 6 or 14 days. Chemical analysis revealed that DBDPE and BDE209 were bioconcentrated in zebrafish larvae, with similar magnitudes of accumulated concentrations. Based on screened by chromatograms, at least seven unknown compounds were observed in DBDPE-treated larvae, indicating biotransformation of the chemical. Significant increases in whole body content of triiodothyronine (T3) and thyroxine (T4) were detected in DBDPE-treated larvae, but decreased in BDE209-treated groups. Alterations in gene transcription along the related hypothalamic-pituitary-thyroid (HPT) axis were observed. Furthermore, the binding and transport protein transthyretin (TTR) was significantly increased in DBDPE exposure groups. Histological examination and stereological analysis showed no obvious pathological changes in the thyroid gland. The present study demonstrates for the first time the bioavailability, biotransformation and thyroid endocrine disruption associated with DBDPE exposure in fish. Further studies are warranted to identify the metabolites of DBDPE and to define its environmental risks to aquatic organisms. |
| WOS研究方向 | Zoology ; Biochemistry & Molecular Biology ; Endocrinology & Metabolism ; Developmental Biology ; Genetics & Heredity ; Environmental Sciences & Ecology |
| 语种 | 英语 |
| WOS记录号 | WOS:ZOOR15512082126 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/35399]  |
| 专题 | 水生生物研究所_水环境工程研究中心_期刊论文 |
| 作者单位 | Chinese Acad Sci, Inst Hydrobiol, Wuhan, Hubei, 430072, China |
| 推荐引用方式 GB/T 7714 | Wang, Xiaochen,Ling, Siyuan,Guan, Kelan,et al. Bioconcentration, Biotransformation, and Thyroid Endocrine Disruption of Decabromodiphenyl Ethane (Dbdpe), A Novel Brominated Flame Retardant, in Zebrafish Larvae.[J]. Environmental Science & Technology,2019,53(14):8437-8446. |
| APA | Wang, Xiaochen.,Ling, Siyuan.,Guan, Kelan.,Luo, Xiaojun.,Chen, Lianguo.,...&Zhou, Bingsheng.(2019).Bioconcentration, Biotransformation, and Thyroid Endocrine Disruption of Decabromodiphenyl Ethane (Dbdpe), A Novel Brominated Flame Retardant, in Zebrafish Larvae..Environmental Science & Technology,53(14),8437-8446. |
| MLA | Wang, Xiaochen,et al."Bioconcentration, Biotransformation, and Thyroid Endocrine Disruption of Decabromodiphenyl Ethane (Dbdpe), A Novel Brominated Flame Retardant, in Zebrafish Larvae.".Environmental Science & Technology 53.14(2019):8437-8446. |
入库方式： OAI收割
来源：水生生物研究所
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