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Zebrafish prmt7 negatively regulates antiviral responses by suppressing the retinoic acid-inducible gene-I-like receptor signaling

文献类型：期刊论文

作者Zhu, Junji4,5; Liu, Xing1,3,5; Cai, Xiaolian4,5; Ouyang, Gang1,3,5; Fan, Sijia4,5; Wang, Jing1,3,5; Xiao, Wuhan1,2,3,4,5
刊名FASEB JOURNAL
出版日期2020
卷号34期号:1页码:988-1000
关键词GCRV irf3 Prmt7 SVCV zebrafish
ISSN号0892-6638
DOI10.1096/fj.201902219R
通讯作者Xiao, Wuhan(w-xiao@ihb.ac.cn)
英文摘要Arginine methylation is a post-translational modification in histone and nonhistone proteins that can affect numerous cellular activities. Protein arginine methyltransferase 7 (Prmt7), a type III arginine methyltransferase, catalyzes the formation of stable monomethylarginines of histones. The role of PRMT7 in virus-induced innate immunity signaling, however, remains largely unknown. We demonstrate that zebrafish prmt7 could be inhibited by spring viremia of carp virus (SVCV) and grass carp reovirus (GCRV) infection. The overexpression of prmt7 suppresses cellular antiviral responses that are partially dependent on the arginine methyltransferase activity of prmt7. Consistently, prmt7-null zebrafish were more resistant to SVCV or GCRV infection, exhibiting enhanced expression of key antiviral genes and fewer necrotic cells in the liver and kidney upon viral infection. Furthermore, we established a zebrafish model to investigate grass carp hemorrhagic disease. Our findings suggest that by suppressing the RIG-I-like receptors signaling, zebrafish prmt7 negatively regulates antiviral responses, indicating the vital role of prmt7 and its arginine methyltransferase activity in innate immunity.
WOS关键词PROTEIN ARGININE METHYLTRANSFERASE ; GRASS CARP REOVIRUS ; SPRING VIREMIA ; 7 PRMT7 ; RECOGNITION ; METHYLATION ; RNA ; METASTASIS ; INDUCTION ; CELLS
资助项目National Natural Science Foundation of China (NSFC)[31830101] ; National Natural Science Foundation of China (NSFC)[31721005] ; National Natural Science Foundation of China (NSFC)[31631102] ; National Natural Science Foundation of China (NSFC)[31671315] ; National Key R & D Program of China[2018YFD0900602]
WOS研究方向Biochemistry & Molecular Biology ; Life Sciences & Biomedicine - Other Topics ; Cell Biology
语种英语
WOS记录号WOS:000507308900067
出版者FEDERATION AMER SOC EXP BIOL
资助机构National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Natural Science Foundation of China (NSFC) ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China ; National Key R & D Program of China
源URL[http://ir.ihb.ac.cn/handle/342005/35465]  
专题水生生物研究所_水环境工程研究中心_期刊论文
通讯作者Xiao, Wuhan
作者单位1.Chinese Acad Sci, Minist Agr, Key Lab Aquaculture Dis Control, Wuhan, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan, Peoples R China
3.Chinese Acad Sci, Innovat Seed Design, Wuhan, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
5.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan, Peoples R China
推荐引用方式
GB/T 7714		 Zhu, Junji,Liu, Xing,Cai, Xiaolian,et al. Zebrafish prmt7 negatively regulates antiviral responses by suppressing the retinoic acid-inducible gene-I-like receptor signaling[J]. FASEB JOURNAL,2020,34(1):988-1000.
APA Zhu, Junji.,Liu, Xing.,Cai, Xiaolian.,Ouyang, Gang.,Fan, Sijia.,...&Xiao, Wuhan.(2020).Zebrafish prmt7 negatively regulates antiviral responses by suppressing the retinoic acid-inducible gene-I-like receptor signaling.FASEB JOURNAL,34(1),988-1000.
MLA Zhu, Junji,et al."Zebrafish prmt7 negatively regulates antiviral responses by suppressing the retinoic acid-inducible gene-I-like receptor signaling".FASEB JOURNAL 34.1(2020):988-1000.

入库方式： OAI收割

来源：水生生物研究所

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