中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
首页 机构 成果 学者
  
  1. CAS IR Grid
  2. 水生生物研究所
  3. 中科院水生所知识产出（2009年前）
  4. 水环境工程研究中心
  5. 期刊论文
Evaluation and mechanistic study of chlordecone-induced thyroid disruption: Based on in vivo, in vitro and in silico assays

文献类型：期刊论文

作者Yang, Lihua3; Zha, Jinmiao1,2; Guo, Yongyong3; Zhou, Bingsheng3
刊名SCIENCE OF THE TOTAL ENVIRONMENT
出版日期2020-05-10
卷号716页码:9
关键词Chlordecone Thyroid disruption Rare minnow GH3 cells Estrogen receptor
ISSN号0048-9697
DOI10.1016/j.scitotenv.2020.136987
通讯作者Zha, Jinmiao(jmzha@rcees.ac.cn)
英文摘要The present study aimed to evaluate the thyroid-disrupting potency of chlordecone, and reveal the underlying mechanism. In the in vivo assays, rare minnow embryos were exposed to 0, 0.01, 0.1, 1 and 10 mu g.L-1 chlordecone until sexually mature. The results showed decreased T4 but increased T3 concentrations in plasma, upregulated mRNA levels of thyrotropin-releasing hormone receptor (n hr) and sodium-iodide symporter (nis) in the brain, and transthyretin (ttr), thyroid hormone receptor alpha (tr alpha) and deiodinase enzymes (dio1 and dio2) in the liver of adult fish. In the in vitro assays, single chlordecone treatments promoted growth hormone (GH) and prolactin (PRL) secretion in GH3 cells. Transcription of thyroid receptor (tr beta) was inhibited, but this is not likely responsible for chlordecone-induced GH secretion and altered transcription. When co-treated with T3, chlordecone acted independently of the effect of T3 on GH secretion: chlordecone-induced GH/PRL secretion and mRNA expression were further promoted when co-treated with E2, but inhibited when co-treated with ICE indicating an important role for estrogen receptors (ERs) in chlordecone-induced changes in GH3 cells. Further-more, in silico prediction suggested no stable interactions between chlordecone and thyroid hormone-related proteins, as well as a regulatory role for ERs in thyroid systems. Overall, our results indicated that chlordecone may have adverse effects on thyroid systems upon long-term exposure. However, rather of TRs, ERs may be responsible for thyroid disruption following chlordecone exposure. (C) 2020 Elsevier B.V. All rights reserved.
WOS关键词POLYBROMINATED DIPHENYL ETHERS ; MESSENGER-RNA EXPRESSION ; ENDOCRINE DISRUPTION ; HORMONE-ACTIVITY ; EXPOSURE ; ESTROGEN ; TRANSCRIPTION ; EPIDEMIOLOGY ; RECEPTORS ; CHEMICALS
资助项目National Key Research and Development Program of China[2018YFD0900701] ; National S&T BasicWork of China[2014FY120200]
WOS研究方向Environmental Sciences & Ecology
语种英语
WOS记录号WOS:000519987300064
出版者ELSEVIER
资助机构National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China ; National S&T BasicWork of China
源URL[http://ir.ihb.ac.cn/handle/342005/35986]  
专题水生生物研究所_水环境工程研究中心_期刊论文
通讯作者Zha, Jinmiao
作者单位1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Beijing Key Lab Ind Wastewater Treatment & Reuse, Beijing 100085, Peoples R China
2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Drinking Water Sci & Technol, Beijing 100085, Peoples R China
3.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Lihua,Zha, Jinmiao,Guo, Yongyong,et al. Evaluation and mechanistic study of chlordecone-induced thyroid disruption: Based on in vivo, in vitro and in silico assays[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2020,716:9.
APA Yang, Lihua,Zha, Jinmiao,Guo, Yongyong,&Zhou, Bingsheng.(2020).Evaluation and mechanistic study of chlordecone-induced thyroid disruption: Based on in vivo, in vitro and in silico assays.SCIENCE OF THE TOTAL ENVIRONMENT,716,9.
MLA Yang, Lihua,et al."Evaluation and mechanistic study of chlordecone-induced thyroid disruption: Based on in vivo, in vitro and in silico assays".SCIENCE OF THE TOTAL ENVIRONMENT 716(2020):9.

入库方式： OAI收割

来源：水生生物研究所

浏览0
下载0
收藏0
其他版本

除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。