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Zebrafish NF-kappa B/p65 Is Required for Antiviral Responses

文献类型：期刊论文

作者Ouyang, Gang1,3,4,5,6; Liao, Qian1,3,4,5,6; Zhang, Dawei1,3,4,5,6; Rong, Fangjing1,3,4,5,6; Cai, Xiaolian1,3,4,5,6; Fan, Sijia1,3,4,5,6; Zhu, Junji1,3,4,5,6; Wang, Jing1,3,4,5,6; Liu, Xing1,3,4,5,6; Liu, Xueqin2
刊名JOURNAL OF IMMUNOLOGY
出版日期2020-06-01
卷号204期号:11页码:3019-3029
ISSN号0022-1767
DOI10.4049/jimmunol.1900309
通讯作者Xiao, Wuhan(w-xiao@ihb.ac.cn)
英文摘要Transcriptional programs regulated by the NF-kappa B family are essential for the inflammatory response as well as for innate and adaptive immunity. NF-kappa B activation occurs via two major signaling pathways: the canonical and the noncanonical. The canonical NF-kappa B pathway responds to diverse immune stimulations and leads to rapid but transient activation. As a member of the canonical NF-kappa B family, p65 is thought to be a key regulator of viral infection. Because of the embryonic lethality of p65-null mice, the physiological role of p65 in the antiviral immune response is still unclear. In this study, we generated p65-null zebrafish, which were viable and indistinguishable from their wildtype (WT) siblings under normal conditions. However, p65-null zebrafish were more sensitive to spring viremia of carp virus infection than their WT siblings. Further assays indicated that proinflammatory and antiviral genes, including IFN, were downregulated in p65-null zebrafish after spring viremia of carp virus infection compared with their WT siblings. Our results thus suggested that p65 is required for the antiviral response, activating not only proinflammatory genes but also antiviral genes (including IFN).
WOS关键词NF-KAPPA-B ; MESSENGER-RNA DECAY ; SPRING VIREMIA ; RELA ; FISH ; IMMUNITY ; RESCUES ; MICE ; P65
资助项目National Natural Science Foundation of China[31721005] ; National Natural Science Foundation of China[31830101] ; National Natural Science Foundation of China[31671315] ; National Key R&D Program of China[2018YFA0801000] ; National Key R&D Program of China[2018YFD0900602] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA24010308]
WOS研究方向Immunology
语种英语
WOS记录号WOS:000534598700015
出版者AMER ASSOC IMMUNOLOGISTS
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Strategic Priority Research Program of the Chinese Academy of Sciences
源URL[http://ir.ihb.ac.cn/handle/342005/36518]  
专题水生生物研究所_水环境工程研究中心_期刊论文
通讯作者Xiao, Wuhan
作者单位1.Minist Agr, Key Lab Aquaculture Dis Control, Wuhan 430072, Peoples R China
2.Huazhong Agr Univ, Coll Fisheries, Wuhan 430070, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Innovat Acad Seed Design, Wuhan 430072, Peoples R China
5.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquat Biodivers & Conservat, Wuhan 430072, Peoples R China
6.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China
推荐引用方式
GB/T 7714		 Ouyang, Gang,Liao, Qian,Zhang, Dawei,et al. Zebrafish NF-kappa B/p65 Is Required for Antiviral Responses[J]. JOURNAL OF IMMUNOLOGY,2020,204(11):3019-3029.
APA Ouyang, Gang.,Liao, Qian.,Zhang, Dawei.,Rong, Fangjing.,Cai, Xiaolian.,...&Xiao, Wuhan.(2020).Zebrafish NF-kappa B/p65 Is Required for Antiviral Responses.JOURNAL OF IMMUNOLOGY,204(11),3019-3029.
MLA Ouyang, Gang,et al."Zebrafish NF-kappa B/p65 Is Required for Antiviral Responses".JOURNAL OF IMMUNOLOGY 204.11(2020):3019-3029.

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来源：水生生物研究所

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