Grass carp reovirus VP56 represses interferon production by degrading phosphorylated IRF7
文献类型:期刊论文
作者 | Zhang, Can2,3; Lu, Long-Feng3; Li, Zhuo-Cong2,3; Zhou, Xiao-Yu2,3; Zhou, Yu2,3; Chen, Dan-Dan3; Li, Shun3; Zhang, Yong-An1,3 |
刊名 | FISH & SHELLFISH IMMUNOLOGY |
出版日期 | 2020-04-01 |
卷号 | 99期号:1页码:99-106 |
ISSN号 | 1050-4648 |
关键词 | VP56 GCRV Immune evasion IRF7 Interferon |
DOI | 10.1016/j.fsi.2020.02.004 |
英文摘要 | Grass carp reovirus (GCRV) is an efficient pathogen causing high mortality in grass carp, meanwhile, fish interferon (IFN) is a powerful cytokine enabling host cells to establish an antiviral state; therefore, the strategies used by GCRV to escape the cellular IFN response need to be investigated. Here, we report that GCRV VP56 inhibits host IFN production by degrading the transcription factor IFN regulatory factor 7 (IRF7). First, overexpression of VP56 inhibited the IFN production induced by the polyinosinic-polycytidylic acid (poly I:C) and mitochondrial antiviral signaling protein (MAVS), while the capacity of IRF7 on IFN induction was unaffected. Second, VP56 interacted with RLRs but did not affect the stabilization of the proteins in the normal state, while the phosphorylated IRF7 activated by TBK1 was degraded by VP56 through K48-linked ubiquitination. Finally, overexpression of VP56 remarkably reduced the host cellular ifn transcription and facilitated viral proliferation. Taken together, our results demonstrate that GCRV VP56 suppresses the host IFN response by targeting phosphorylated IRF7 for ubiquitination and degradation. |
WOS关键词 | ANTIVIRAL SIGNALING PROTEIN ; COMPLETE GENOME SEQUENCE ; INNATE IMMUNE-RESPONSE ; PATHOGEN RECOGNITION ; ADAPTER PROTEIN ; VIRUS ; GENE ; IDENTIFICATION ; EXPRESSION ; INDUCTION |
WOS研究方向 | Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences |
语种 | 英语 |
出版者 | ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD |
WOS记录号 | WOS:000523601500011 |
源URL | [http://ir.ihb.ac.cn/handle/342005/36073] |
专题 | 水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文 |
通讯作者 | Li, Shun; Zhang, Yong-An |
作者单位 | 1.Huazhong Agr Univ, Coll Fisheries, State Key Lab Agr Microbiol, Wuhan, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Hydrobiol, Wuhan 430072, Peoples R China |
推荐引用方式 GB/T 7714 | Zhang, Can,Lu, Long-Feng,Li, Zhuo-Cong,et al. Grass carp reovirus VP56 represses interferon production by degrading phosphorylated IRF7[J]. FISH & SHELLFISH IMMUNOLOGY,2020,99(1):99-106. |
APA | Zhang, Can.,Lu, Long-Feng.,Li, Zhuo-Cong.,Zhou, Xiao-Yu.,Zhou, Yu.,...&Zhang, Yong-An.(2020).Grass carp reovirus VP56 represses interferon production by degrading phosphorylated IRF7.FISH & SHELLFISH IMMUNOLOGY,99(1),99-106. |
MLA | Zhang, Can,et al."Grass carp reovirus VP56 represses interferon production by degrading phosphorylated IRF7".FISH & SHELLFISH IMMUNOLOGY 99.1(2020):99-106. |
入库方式: OAI收割
来源:水生生物研究所
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