In Primitive Zebrafish, MHC Class II Expression Is Regulated by IFN-gamma, IRF1, and Two Forms of CIITA
文献类型:期刊论文
作者 | Hou, Jing1,4,5,6,7; Chen, Shan Nan1,7; Gan, Zhen1,7; Li, Nan1,7; Huang, Lin1,7; Huo, Hui Jun1,7; Yang, Yue Cong1,7; Lu, Yishan4,5; Yin, Zhan1,7; Nie, Pin1,2,3,7 |
刊名 | JOURNAL OF IMMUNOLOGY |
出版日期 | 2020-05-01 |
卷号 | 204期号:9页码:2401-2415 |
ISSN号 | 0022-1767 |
DOI | 10.4049/jimmunol.1801480 |
通讯作者 | Nie, Pin(pinnie@ihb.ac.cn) |
英文摘要 | Mammalian CIITA isoforms are tightly regulated by independent promoters. These promotors are induced by IFN-g through JAK-STAT signaling pathway. The induction of CIITA controls the expression of MHC class II (MHCII) and Ag presentation to the adaptive immune system. In the current study, to our knowledge, we first identified two independent promoters, p1 and p2, in the zebrafish ( Danio rerio) that control the expression of the two variants of CIITA, CIITA variant 1 (CIITAv1), and CIITA variant 2 (CIITAv2), respectively. Moreover, although IRF1 in an IFN-gamma signaling pathway induced CIITAv2, which has two ISRE motifs in its promoter, CIITAv1 expression was not induced by this signal. Further, the transcription of MHCII DAB was controlled by IRF1 via two distinct mechanisms: 1) the transcription of MHCII DAB was controlled by IRF1 indirectly through the two ISREs in p2; and 2) directly via the ISRE in MHCII DAB promoter. We also found that IRF1 associated with CIITAv1 and CIITAv2 via protein-protein interactions to synergistically drive the transcription of MHCII DAB. The IFN-gamma-IRF1-CIITA-MHCII signaling cascade was functional in early life stages of CIITA(-/-) and IRF1(-/-) zebrafish. Our findings imply that the immune system develops early in fishes and that the IFN-g signaling cascade-induced CIITA and MHCII DAB is conserved in teleost fishes and mammals. |
WOS关键词 | OPEN READING FRAMES ; BARE LYMPHOCYTE SYNDROME ; MICE LACKING ; TRANSCRIPTION FACTORS ; MOLECULAR-MECHANISMS ; EARLY MACROPHAGES ; PROMOTER ; GENES ; UPSTREAM ; ACTIVATION |
资助项目 | National Natural Science Foundation of China[31320103913] ; China Agriculture Research System[CARS46] ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China[(2018)8] ; First class fishery discipline program in Shandong Province, China[(2018)27] |
WOS研究方向 | Immunology |
语种 | 英语 |
出版者 | AMER ASSOC IMMUNOLOGISTS |
WOS记录号 | WOS:000528255900009 |
资助机构 | National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; China Agriculture Research System ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; special top talent plan One Thing One Decision (Yishi Yiyi) in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China ; First class fishery discipline program in Shandong Province, China |
源URL | [http://ir.ihb.ac.cn/handle/342005/36407] |
专题 | 水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文 |
通讯作者 | Nie, Pin |
作者单位 | 1.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Hubei, Peoples R China 2.Qingdao Agr Univ, Sch Marine Sci & Engn, Qingdao 266109, Shandong, Peoples R China 3.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China 4.Guangdong Ocean Univ, Coll Fisheries, Prov Key Lab Pathogen Biol & Epidemiol Aquat Anim, Zhanjiang 524088, Guangdong, Peoples R China 5.Guangdong Ocean Univ, Shenzhen Inst, Shenzhen 518120, Guangdong, Peoples R China 6.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 7.Chinese Acad Sci, Inst Hydrobiol, Key Lab Aquaculture Dis Control, Wuhan 430072, Hubei, Peoples R China |
推荐引用方式 GB/T 7714 | Hou, Jing,Chen, Shan Nan,Gan, Zhen,et al. In Primitive Zebrafish, MHC Class II Expression Is Regulated by IFN-gamma, IRF1, and Two Forms of CIITA[J]. JOURNAL OF IMMUNOLOGY,2020,204(9):2401-2415. |
APA | Hou, Jing.,Chen, Shan Nan.,Gan, Zhen.,Li, Nan.,Huang, Lin.,...&Nie, Pin.(2020).In Primitive Zebrafish, MHC Class II Expression Is Regulated by IFN-gamma, IRF1, and Two Forms of CIITA.JOURNAL OF IMMUNOLOGY,204(9),2401-2415. |
MLA | Hou, Jing,et al."In Primitive Zebrafish, MHC Class II Expression Is Regulated by IFN-gamma, IRF1, and Two Forms of CIITA".JOURNAL OF IMMUNOLOGY 204.9(2020):2401-2415. |
入库方式: OAI收割
来源:水生生物研究所
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