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  5. 期刊论文
Ca2+ plays an antiviral role by increasing p53 expression to achieve protection against spring viraemia of carp virus infection

文献类型：期刊论文

作者Lu, Long-Feng2; Zhou, Xiao-Yu2,5; Zhang, Can2,4; Li, Zhuo-Cong2,4; Chen, Dan-Dan2; Zhang, Yong-An1,2,3; Li, Shun2
刊名FISH & SHELLFISH IMMUNOLOGY
出版日期2020-07-01
卷号102页码:449-459
ISSN号1050-4648
关键词Ca2+ Antiviral p53 Ubiquitination SVCV
DOI10.1016/j.fsi.2020.05.023
通讯作者Zhang, Yong-An(yonganzhang@mail.hzau.edu.cn) ; Li, Shun(bob@ihb.ac.cn)
英文摘要Calcium (Ca) is a messenger that regulates a multitude of physiological processes, but its functions in antiviral progress remain undefined. In this study, we found that Ca-2(+) enhances fish survival to defend against spring viraemia of carp virus (SVCV) infection by reversing the instability of p53 mediated by the viral protein. First, Ca-2(+) significantly protected cells and fish against SVCV infection by inducing early apoptosis. Additionally, p53 expression, which was inhibited by SVCV N protein, was upregulated by Ca-2(+) treatment. Then, the mechanism underlying the reduction of K63-linked p53 ubiquitination by SVCV N protein via the K358 site was completely prevented by Ca-2(+). These findings reveal the role of Ca-2(+) in lower vertebrates in the antiviral response, which is connected to and corresponds with viral immune evasion, providing a solution to fish diseases caused by pathogens.
WOS关键词CELL-DEATH ; CALCIUM ; APOPTOSIS ; PROTEIN ; MANGANESE ; GENE ; INHIBITION ; DIVERSITY ; IMMUNITY ; INNATE
资助项目National Natural Science Foundation of China[31725026] ; National Natural Science Foundation of China[31802338] ; National Key Research and Development Program of China[2018YFD0900504] ; Youth Innovation Promotion Association
WOS研究方向Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
语种英语
出版者ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
WOS记录号WOS:000537822700049
资助机构National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; National Key Research and Development Program of China ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association ; Youth Innovation Promotion Association
源URL[http://ir.ihb.ac.cn/handle/342005/36692]  
专题水生生物研究所_水生生物分子与细胞生物学研究中心_期刊论文
通讯作者Zhang, Yong-An; Li, Shun
作者单位1.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao, Peoples R China
2.Chinese Acad Sci, Inst Hydrobiol, Wuhan, Peoples R China
3.Huazhong Agr Univ, Coll Fisheries, State Key Lab Agr Microbiol, Wuhan, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
5.Dalian Ocean Univ, Coll Fisheries & Life Sci, Dalian, Peoples R China
推荐引用方式
GB/T 7714		 Lu, Long-Feng,Zhou, Xiao-Yu,Zhang, Can,et al. Ca2+ plays an antiviral role by increasing p53 expression to achieve protection against spring viraemia of carp virus infection[J]. FISH & SHELLFISH IMMUNOLOGY,2020,102:449-459.
APA Lu, Long-Feng.,Zhou, Xiao-Yu.,Zhang, Can.,Li, Zhuo-Cong.,Chen, Dan-Dan.,...&Li, Shun.(2020).Ca2+ plays an antiviral role by increasing p53 expression to achieve protection against spring viraemia of carp virus infection.FISH & SHELLFISH IMMUNOLOGY,102,449-459.
MLA Lu, Long-Feng,et al."Ca2+ plays an antiviral role by increasing p53 expression to achieve protection against spring viraemia of carp virus infection".FISH & SHELLFISH IMMUNOLOGY 102(2020):449-459.

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来源：水生生物研究所

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